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Techniques for Detection of Clinical Used Heparins. | LitMetric

Techniques for Detection of Clinical Used Heparins.

Int J Anal Chem

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.

Published: May 2021

Heparins and sulfated polysaccharides have been recognized as effective clinical anticoagulants for several decades. Heparins exhibit heterogeneity depending on the sources. Meanwhile, the adverse effect in the clinical uses and the adulteration of oversulfated chondroitin sulfate (OSCS) in heparins develop additional attention to analyze the purity of heparins. This review starts with the description of the classification, anticoagulant mechanism, clinical application of heparins and focuses on the existing methods of heparin analysis and detection including traditional detection methods, as well as new methods using fluorescence or gold nanomaterials as probes. The in-depth understanding of these techniques for the analysis of heparins will lay a foundation for the further development of novel methods for the detection of heparins.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121598PMC
http://dx.doi.org/10.1155/2021/5543460DOI Listing

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