C1-C2 arthrodesis is a common procedure performed for the correction of atlantoaxial instability due to a host of pathologies, including degenerative, neoplastic, congenital, and trauma. While there is clinical equipoise, C1-C2 fusion is associated with a lower morbidity than occipital-cervical fusion. However, due to the unique morphometric characteristics of the C1 lateral mass, and the challenges that its fixation presents, some surgeons may elect to extend the construct to the occiput rather than attempt a C1-C2 fusion. Here, we describe our freehand technique of safely and expeditiously performing a C1-C2 fusion with C1 lateral mass and C2 "parsicle" screws. In patients with high preprocedural probability to develop pseudarthrosis, we combine our instrumented fusion with interlaminar bone graft wiring, as similarly described by Gallie. We believe the C2 "parsicle" screw avoids the technical challenges of placing a traditional C2 pedicle screw and accommodates a much larger screw length than those placed in the C2 pars. Practical surgical tips, pearls, and potential complications are discussed in detail.
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http://dx.doi.org/10.1097/BSD.0000000000001210 | DOI Listing |
PLoS One
December 2024
Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America.
Ataxin-2 is a protein containing a polyQ extension and intermediate length of polyQ extensions increases the risk of Amyotrophic Lateral Sclerosis (ALS). Down-regulation of Ataxin-2 has been shown to mitigate TDP-43 proteinopathy in ALS models. To identify alternative therapeutic targets that can mitigate TDP-43 toxicity, we examined the interaction between Ataxin-2 and TDP-43.
View Article and Find Full Text PDFRev Bras Ortop (Sao Paulo)
November 2024
Instituto Vita, São Paulo, São Paulo, Brasil.
Common fibular nerve (CFN) palsy is the most common mononeuropathy in the lower limb, and several etiologies are described. The CFN is the minor and lateral division of the sciatic nerve; it originates in the lumbar sacral division, and many risks of compression have been described: the behavior of crossing and squatting legs, extra and intraneural compressions, local trauma, and weight loss have been increasingly reported as important and noteworthy causes. The treatment is based on the severity of the nerve condition.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Civil Engineering, Mehmet Akif Ersoy University, Burdur, Turkey.
Civil structures are prone to dynamic loadings such as strong winds or ground excitations where torsion becomes an ongoing issue. This arises from a lack of coincidence of the center of mass (CM) and rigidity (CR), known as eccentricity. Seismic design codes often introduce two types of eccentricity: inherent (geometric) and accidental.
View Article and Find Full Text PDFJ Fungi (Basel)
November 2024
Department of Chemistry, Colorado State University, 1801 Campus Delivery, Fort Collins, CO 80523, USA.
In the last decade, pulmonary fungal infections such as invasive pulmonary aspergillosis (IPA) have increased in incidence due to the increased number of immunocompromised individuals. This increase is especially problematic when considering mortality rates associated with IPA are upwards of 70%. This high mortality rate is due to, in part, the length of time it takes to diagnose a patient with IPA.
View Article and Find Full Text PDFJ Funct Morphol Kinesiol
November 2024
Institute of Sport Science, School of Humanities and Social Sciences, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
Background/objectives: Core strength diagnostics often focus on measuring core endurance rather than maximal core strength or core power. This study investigates whether core strength can be considered as a general ability that can be measured by a single core strength test or whether it needs to be differentiated into several components.
Methods: Forty-two adult sports students ( = 20; = 22; age: 24.
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