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Antimycobacterial activity of (Asteraceae) aqueous extract from Southern Brazil. | LitMetric
aqueous extract was obtained by macerating wildflowers. The phytochemical profile present in the aqueous extract was elucidated by HPLC-ESI-MS/MS. Toxicity was evaluated by comet assay in peripheral blood mononuclear cells (PBMCs) and using as a model. The antioxidant activity was also evaluated, and antimycobacterial activity was assessed by the broth microdilution method. The compounds present in the aqueous extract mainly belonged to the flavonoid class (89%). The concentrations that showed protective effects in against oxidative stress and antimycobacterial activity had no toxic effects. The antimycobacterial activity test demonstrated that the concentration of 1,560 µg mL inhibited the growth and eradication of the mycobacterial tested strains. Based on our findings, the aqueous extract presents a viable potential in developing new phytotherapeutic drugs against mycobacteria of clinical relevance.
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