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Task-dependent mixed selectivity in the subiculum. | LitMetric

Task-dependent mixed selectivity in the subiculum.

Cell Rep

Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway. Electronic address:

Published: May 2021

AI Article Synopsis

  • CA1 and subiculum (SUB) are interconnected regions that link the hippocampus to various output areas and both exhibit place-specific firing patterns, though SUB shows more dispersion.
  • Research indicates that both regions have weak responses to head direction and running speed, and the encoding of this information is not well understood.
  • The study highlights that individual neurons in both CA1 and SUB respond to positional, directional, and speed cues, with SUB demonstrating stronger mixed representation, particularly during goal-directed navigation, suggesting it may enhance the efficiency of hippocampal information transfer to other brain regions.*

Article Abstract

CA1 and subiculum (SUB) connect the hippocampus to numerous output regions. Cells in both areas have place-specific firing fields, although they are more dispersed in SUB. Weak responses to head direction and running speed have been reported in both regions. However, how such information is encoded in CA1 and SUB and the resulting impact on downstream targets are poorly understood. Here, we estimate the tuning of simultaneously recorded CA1 and SUB cells to position, head direction, and speed. Individual neurons respond conjunctively to these covariates in both regions, but the degree of mixed representation is stronger in SUB, and more so during goal-directed spatial navigation than free foraging. Each navigational variable could be decoded with higher precision, from a similar number of neurons, in SUB than CA1. The findings point to a possible contribution of mixed-selective coding in SUB to efficient transmission of hippocampal representations to widespread brain regions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170370PMC
http://dx.doi.org/10.1016/j.celrep.2021.109175DOI Listing

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