AI Article Synopsis
- The study aimed to investigate how changes in liver fat after gastric banding surgery affect insulin sensitivity and β-cell function over a 2-year period.
- It included 23 adults with prediabetes or type 2 diabetes and measured body fat, liver fat content, insulin sensitivity, and β-cell responses before and after the surgery.
- Results showed that lowering liver fat was strongly linked to improved insulin sensitivity, with significant reductions in glucose levels and improvements in glycemic measures correlated with greater liver fat loss.
Article Abstract
Objective: The aim of this study was to examine the relationship between changes in liver fat and changes in insulin sensitivity and β-cell function 2 years after gastric banding surgery.
Methods: Data included 23 adults with the surgery who had prediabetes or type 2 diabetes for less than 1 year and BMI 30 to 40 kg/m at baseline. Body adiposity measures including liver fat content (LFC), insulin sensitivity (M/I), and β-cell responses (acute, steady-state, and arginine-stimulated maximum C-peptide) were assessed at baseline and 2 years after surgery. Regression models were used to assess associations adjusted for age and sex.
Results: Two years after surgery, all measures of body adiposity, LFC, fasting and 2-hour glucose, and hemoglobin A1c significantly decreased; M/I significantly increased; and β-cell responses adjusted for M/I did not change significantly. Among adiposity measures, reduction in LFC had the strongest association with M/I increase (r = -0.61, P = 0.003). Among β-cell measures, change in LFC was associated with change in acute C-peptide response to arginine at maximal glycemic potentiation adjusted for M/I (r = 0.66, P = 0.007). Significant reductions in glycemic measures and increase in M/I were observed in individuals with LFC loss >2.5%.
Conclusions: Reduction in LFC after gastric banding surgery appears to be an important factor associated with long-term improvements in insulin sensitivity and glycemic profiles in adults with obesity and prediabetes or early type 2 diabetes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222142 | PMC |
| http://dx.doi.org/10.1002/oby.23174 | DOI Listing |
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