Sterilizing immunity: New opportunities for rational TB vaccine design.

J Exp Med

Department of Microbiology and Molecular Genetics and Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Published: July 2021

Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector mechanisms that when triggered by appropriately engineered vaccines could end TB's deadly reign.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160586PMC
http://dx.doi.org/10.1084/jem.20210454DOI Listing

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