Intermediate snapshots of a 116-nuclear metallosupramolecular cage-of-cage in a homogeneous single-crystal-to-single-crystal transformation.

Soaking crystals of an AuI72CdII40NaI4 cage-of-cage in aqueous Co(NO3)2 afforded an analogous AuI72CoII44 cage-of-cage, accompanied by the exchange of NaI and CdII by CoII with retention of the single crystallinity. The homogeneous progress of the transformation led to the direct observation of intermediate species by single-crystal X-ray crystallography.