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Alternative mechanism of action of the DNP Pt prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway. | LitMetric
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Alternative mechanism of action of the DNP Pt prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway.

Olga Krasnovskaya Daniil Spector Alexander Erofeev Peter Gorelkin Roman Akasov Dmitry Skvortsov Alexander Trigub Ksenia Vlasova Alevtina Semkina Nikolay Zyk Elena Beloglazkina Alexander Majouga

Dalton Trans

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1, 3, Moscow, 119991, Russia. and National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow, 101000, Russia and Mendeleev University of Chemical Technology of Russia, Miusskaya Ploshchad' 9, Moscow, 125047, Russia.

Published: June 2021

In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.

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http://dx.doi.org/10.1039/d1dt00898fDOI Listing

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