AI Article Synopsis
- Peptide self-assembly is used to create biocompatible biomaterials that mimic natural proteins for applications in biotechnology.
- The study introduces a new β-amino acid that enables the creation of a trifunctional β-tripeptide, which retains its ability to self-assemble despite having bulky sidechains.
- These novel β-tripeptides serve as bioactive scaffolds, showing potential for promoting neuronal cell growth and supporting research in neuronal development.
Article Abstract
Peptide self-assembly has been exploited to generate a multitude of biomaterials that exhibit biocompatibility due to their similarity to naturally occurring proteins. Previously, we have shown that β-tripeptides self-assemble despite containing sterically bulky, functional sidechains. Herein, we describe the synthesis of a novel β-amino acid to allow for the synthesis of a trifunctional β-tripeptide that remarkably maintains self-assembly and acts as a bioactive neuronal scaffold. These scaffolds show promise for studies involving neuronal cell growth and development.
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| http://dx.doi.org/10.1039/d0tb02959a | DOI Listing |
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