Single Nucleotide Polymorphisms as the Efficient Prognostic Markers in Breast Cancer.

Background: Breast cancer (BC) is known as the most common malignancy in women. Environmental and genetic factors are associated with BC progression. Genetic polymorphisms have been reported as important risk factors for BC prognosis and drug response. Main Body: In the present review, we have summarized all of the single nucleotide polymorphisms (SNPs) which have been significantly associated with drug response in BC patients in the world. We have also categorized the reported SNPs based on their related gene functions to clarify the molecular biology of drug responses in BC.

Conclusion: The majority of SNPs were reported in detoxifying enzymes which introduced such genes as the main genetic risk factors during BC drug responses. This review paves the way for introducing a prognostic panel of SNPs for the BC patients in the world.