Purpose: To explore candidate RayStation beam models to serve as a class-specific template for a TrueBeam treatment delivery system.
Methods: Established validation techniques were used to evaluate three photon beam models: a clinically optimized model from the authors' institution, the built-in RayStation template, and a hybrid consisting of the RayStation template except substituting average MLC parameter values from a recent IROC survey. Comparisons were made for output factors, dose profiles from open fields, as well as representative VMAT test plans.
Results: For jaw-defined output factors, each beam model was within 1.6% of expected published values. Similarly, the majority (57-66%) of jaw-defined dose curves from each model had a gamma pass rate >95% (2% / 3 mm, 20% threshold) when compared to TrueBeam representative beam data. For dose curves from MPPG 5.a MLC-defined fields, average gamma pass rates (1% / 1 mm, 20% threshold) were 92.9%, 85.1%, and 86.0% for the clinical, template, and hybrid models, respectively. For VMAT test plans measured with a diode array detector, median dose differences were 0.6%, 1.3%, and 1.1% for the clinical, template, and hybrid models, respectively. For in-phantom ionization chamber measurements with the same VMAT test plans, the average percent difference was -0.3%, -1.4%, and -1.0% for the clinical, template, and hybrid models, respectively.
Conclusion: Beam model templates taken from the vendor and aggregate results within the community were both reasonable starting points, but neither approach was as optimal as a clinically tuned model, the latter producing better agreement with all validation measurements. Given these results, the clinically optimized model represents a better candidate as a consensus template. This can benefit the community by reducing commissioning time and improving dose calculation accuracy for matched TrueBeam treatment delivery systems.
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http://dx.doi.org/10.1002/acm2.13278 | DOI Listing |
Langmuir
January 2025
Dipartimento di Fisica e Chimica - Emilio Segré, Università degli Studi di Palermo, Viale delle Scienze ed. 18, 90128 Palermo, Italy.
Amyloid fibrils have recently emerged as promising building blocks for functional materials due to their exceptional physicochemical stability and adaptable properties. These protein-based structures can be functionalized to create hybrid materials with a diverse range of applications. Here we report a simple eco-friendly protocol for generating amyloid fibrils from hen egg white lysozyme decorated with gold nanoparticles that can self-assemble in a hydrogel.
View Article and Find Full Text PDFSmall Methods
January 2025
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Rolling circle amplification (RCA)-derived ultra-long DNA is highly attractive and versatile because of its diverse functionalities conferred by repeated DNA nanostructures. However, magnesium pyrophosphate (MgPPi) crystals, as byproducts of RCA, electrostatically interact with the DNA to form DNA microhybrids and hamper its broad bioapplications, as its large size is unfavorable for cellular uptake and decreases the density of functional DNA nanostructures. In this study, finely tuned synthesis strategies are developed to condense the microhybrids and replace non-functional MgPPi crystals with various functional metal nanostructures by reducing metal ions.
View Article and Find Full Text PDFSci Rep
December 2024
Institute of Radioelectronics and Multimedia Technology, Warsaw University of Technology, Warsaw, Poland.
The effects of 5.8-GHz microwave (MW) irradiation on the synthesis of mesoporous selenium nanoparticles (mSeNPs) in aqueous medium by reduction of selenite ions with ascorbic acid, using zinc nanoparticles as a hard template and cetyltrimethylammonium bromide (CTAB) as a micellar template, are examined for the first time with a particular emphasis on MW-particle interactions and the NPs morphology. This MW-assisted synthesis is compared to 2.
View Article and Find Full Text PDFBiosensors (Basel)
December 2024
CUHKSZ-Boyalife Regenerative Medicine Engineering Joint Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.
The Phi29 DNA polymerase is renowned for its processivity in synthesizing single-stranded DNA amplicons by rolling around a circularized DNA template. However, DNA synthesis rolling circle amplification (RCA) is significantly hindered by the secondary structure in the circular template. To overcome this limitation, an engineered circular template without secondary structure could be utilized to improve the sensitivity of RCA-based assays without increasing its complexity.
View Article and Find Full Text PDFOrg Chem Front
December 2024
Department of Chemistry, University of Basel St Johanns-Ring 19 Basel 4056 Switzerland https://www.chemie1.unibas.ch/Bmayor/.
This work explores the use of a cross-shaped organic framework that is used as a template for the investigation of multi-functionalized chromophores. We report the design and synthesis of a universal cross-shaped building block bearing two bromines and two iodines on its peripheral positions. The template can be synthesized on a gram scale in a five-step reaction comprising an oxidative homo-coupling macro-cyclization.
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