Background: A fragility hip fracture is a serious injury in older adults. After experiencing a fracture, a large percentage of patients do not regain their pre-fracture level of mobility. There are several international guidelines recommending early mobility after surgery. We do not know the usage of these early mobility recommendations by health care providers within our institution. An evidence-to-practice gap occurs when there is a failure to implement best practices. Utilization of a systematic method allows for a strategic approach to assessment of an evidence-to-practice gap. There were two aims of this project: a) to describe early mobility activities undertaken on one post surgical unit and, b) to identify if there is an evidence-to-practice gap.
Methods: At a large tertiary centre in Toronto, Ontario, medical records from one calendar year were abstracted for older adults (≥65 years of age) recovering from fragility hip fracture repair. Data were collected regarding demographics, co-morbidities, surgery type, post-operative mobility activities, and any post-operative complications. Primary outcomes were: evidence of early mobility activities and a comparison to Health Quality Ontario recommendations for fragility hip fracture care.
Results: Between 11% and 50% of patients were not participating in early mobility activities. By postoperative day five only two patients had walked over 50 m. Those with low pre-fracture functional ability and a cognitive impairment consistently experienced lower rates of participation compared to patients with high pre-fracture functional ability and no cognitive impairment. Chi-square tests and regression analysis did not reveal any significant associations with variables.
Conclusions: There was very limited participation in early mobility activities after surgery. The study was unable to identify any significant relationships between several variables that may impact participation. This chart review identified the processes that have been sustained and highlights potential areas for future interventions.
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http://dx.doi.org/10.1016/j.ijotn.2021.100846 | DOI Listing |
Eur J Trauma Emerg Surg
January 2025
Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Purpose: This study aims to identify predictors of discharge to post-acute care in geriatric emergency general surgery (EGS) patients.
Methods: This is a retrospective study of geriatric emergency general surgery (EGS) patients at a tertiary care facility between 2017 and 2018. Inclusion criteria were ≥ 65 years old and presented directly from home.
Acta Pharm Sin B
December 2024
Department of Molecular and Life Science, Hanyang University, Ansan 15588, Republic of Korea.
The pathophysiology of sepsis is characterized by a systemic inflammatory response to infection; however, the cytokine blockade that targets a specific early inflammatory mediator, such as tumor necrosis factor, has shown disappointing results in clinical trials. During sepsis, excessive endotoxins are internalized into the cytoplasm of immune cells, resulting in dysregulated pyroptotic cell death, which induces the leakage of late mediator alarmins such as HMGB1 and PTX3. As late mediators of lethal sepsis, overwhelming amounts of alarmins bind to high-affinity TLR4/MD2 and low-affinity RAGE receptors, thereby amplifying inflammation during early-stage sepsis.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Early Prehistory and Quaternary Ecology, Institute of Prehistory, Early History and Medieval Archeology, University of Tübingen, Tübingen, Germany.
Archaeologists can use the provenance of lithic raw materials to examine the movements, territories, and settlement dynamics of hunter-gatherers. Several studies have used macroscopic analyses to propose the long-distance transport of raw material during the Gravettian and the Magdalenian of the Swabian Jura in Central Europe. Until now hypotheses about raw material transport in this region were not based on reproducible analyses.
View Article and Find Full Text PDFActa Orthop
January 2025
Department of Orthopaedic Surgery, Health Møre and Romsdal HF, Kristiansund Hospital, Kristiansund; Department of Neuromedicine and Movement Science, NTNU, Trondheim, Norway.
Background And Purpose: The optimal approach to the hip joint in patients with displaced femoral neck fractures (dFNF) receiving a total hip arthroplasty (THA) remains controversial. We compared the direct lateral approach (DLA) with the direct anterior approach (DAA) primarily on Timed Up and Go (TUG), and secondarily on the Forgotten Joint Score (FJS), the Oxford Hip Score (OHS), EQ5D-5L, and the EQ5D-VAS.
Methods: Between 2018 and 2023, we conducted a randomized controlled trial including elderly patients with dFNFs treated with THA.
Due to their self-renewal and differentiation capabilities, pluripotent stem cells hold immense potential for advancing our understanding of human disease and developing cell-based or pharmacological interventions. Realizing this potential, however, requires a thorough understanding of the basal cellular mechanisms which occur during differentiation. Lipids are critical molecules that define the morphological, biochemical, and functional role of cells.
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