Robert Insall introduces the cytoskeleton special issue and summarises some recent changes in our view of actin function and regulation.
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| http://dx.doi.org/10.1016/j.cub.2021.04.013 | DOI Listing |
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Expression of mTOR, CD163, α-SMA, FOXp3 as survival predictors and its significance in patients with oral squamous cell carcinoma.
BMC Oral Health
December 2024
Department of Biomedical Sciences, Faculty of Biomedical Sciences and Technology, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, 600116, India.
Background: Oral cancer; categorised under head and neck cancers (HNC) predominantly originates from squamous cells and is referred as oral squamous cell carcinoma (OSCC). Various factors (internal and external) causes OSCC. PI3K/AKT/mTOR pathways are known to be primarily mutated in HNC.
View Article and Find Full Text PDFSalmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol.
EMBO Rep
December 2024
Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited to SCVs and function as pro-bacterial organelle.
View Article and Find Full Text PDFGenome-wide association and transcriptomic analysis and the identification of growth-related genes in Macrobrachium nipponense.
BMC Genomics
December 2024
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China.
Macrobrachium nipponense is a commercially important freshwater species of prawn that is widely distributed across Asian countries. In order to investigate the molecular mechanisms of growth in M. nipponense, and to provide a foundation for molecular breeding, we used genome-wide association analysis (GWAS) and transcriptomic analysis to screen polymorphisms and genes related to growth traits.
View Article and Find Full Text PDFEnhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation.
Sci Rep
December 2024
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, Bucharest, 050095, Romania.
Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser irradiation for varying durations, characterized by UV-Vis and FTIR spectroscopy, followed by drug-likeness and ADME-Tox predictions.
View Article and Find Full Text PDFPyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells.
Nat Immunol
December 2024
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
While apoptosis dismantles the cell to enforce immunological silence, pyroptotic cell death provokes inflammation. Little is known of the structural architecture of cells undergoing pyroptosis, and whether pyroptotic corpses are immunogenic. Here we report that inflammasomes trigger the Gasdermin-D- and calcium-dependent eruption of filopodia from the plasma membrane minutes before pyroptotic cell rupture, to crown the resultant corpse with filopodia.
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