AI Article Synopsis
- Antiresorptive therapy is crucial for preventing osteoporotic fractures, but it can lead to a serious side effect known as medication-related osteonecrosis of the jaw (MRONJ).
- A task force reviewed the risk factors and prevention strategies for MRONJ in patients with osteoporosis who need dental work, emphasizing the need for caution among healthcare providers.
- Although MRONJ is rare in these patients, its severity and impact on quality of life make it essential to weigh the risks before proceeding with invasive dental procedures.
Article Abstract
Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528626 | PMC |
| http://dx.doi.org/10.20945/2359-3997000000301 | DOI Listing |
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