The connectome provides large-scale connectivity and morphology information for the majority of the central brain of . Using this data set, we provide a complete description of the olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.
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http://dx.doi.org/10.7554/eLife.66018 | DOI Listing |
Alzheimers Dement
December 2024
Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Despite recognition of the need to increase underrepresented groups (URG) engagement in Alzheimer's disease and related dementias (ADRD) studies, enrollment remains low. As a first step in examining these disparities, these analyses aimed to compare referral sources for Alzheimer's Disease Research Centers (ADRC) enrollment of URG participants.
Method: These analyses included data from 48,330 participants across 46 ADRCs, obtained through the National Alzheimer's Coordinating Center Uniform Data Set.
Alzheimers Dement
December 2024
Florida Atlantic University, Davie, FL, USA.
Background: Acculturation is a relevant variable in the assessment of dementia. Little is known about the type of acculturation scales and the frequency in which they are used in dementia research among Latinos/Hispanics in the US. The purpose of this paper was to conduct a systematic review of published studies that investigated the use of acculturation measures toward Latinos and Hispanics who are diagnosed with dementia.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Background: Majority of people living worldwide live in low- and middle- income countries, including sub-Saharan Africa (SSA). Most cognitive assessment batteries for Alzheimer's Disease(AD), are developed in high income countries (HICs), where most international dementia collaborations and data originate. The African Dementia Consortium (AfDC) is a new scientific collaboration network currently participating in the Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the Alzheimer's Disease Sequencing Project (READD-ADSP).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Video interfacing is increasingly being used in research and health care. The 'VCog' Study seeks to determine whether remote research cognitive assessments are reliable and valid by directly comparing results from in-person administration of a standardized cognitive battery to the same battery administered remotely by video. The study also assesses technology use and comfort amongst participants of varying levels of cognitive impairment.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Virginia, Charlottesville, VA, USA.
Background: The increasing population of older adults and growing number of disease-modifying therapies for Alzheimer's disease (AD) highlight the need for timely differential diagnosis of neurodegenerative disorders despite high referral volumes. This study aimed to develop and pilot a brief neuropsychological battery to evaluate cognitive functioning in adults with suspected AD and improve service delivery by reducing the time between referral and diagnosis.
Methods: Patients were referred to the "early AD pathway" by their neurologist or geriatrician after an initial evaluation in an outpatient multidisciplinary dementia clinic.
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