AI Article Synopsis
- Chronic kidney disease (CKD) negatively impacts growth and cognitive function in children and adolescents, prompting a study to explore intelligence levels and risk factors among this population.
- In the study involving 81 CKD patients under 18, the average IQ was 91, with 24.7% scoring below 80; factors like short stature, severe CKD stages, and longer illness duration correlated with lower IQs.
- Findings suggest a need for further investigation into cognitive impairment related to growth issues in pediatric CKD patients, with early interventions potentially improving IQ outcomes through treatments like kidney transplantation.
Article Abstract
Background: Chronic kidney disease (CKD) has a negative impact on growth and development in children and is a risk factor for neurocognitive impairment; however, there is limited research on the cognitive function of children and adolescents with CKD. This study therefore aimed to investigate the mean intelligence and risk factors for low intelligence in children and adolescents with CKD.
Methods: Eighty-one patients with CKD under 18 years old were included in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Participants completed either the Wechsler Intelligence Scale for Children (6-16 years), or Wechsler Adult Intelligence Scale (> 16 years).
Results: The mean full-scale intelligence quotient (IQ) was 91 ± 19; 24.7% of participants scored a full-scale IQ below 80. Participants with a short stature (height Z scores < -1.88), failure to thrive (weight Z scores < -1.65), more severe CKD stage (≥ IIIb), longer duration of CKD (≥ 5 years), and those who were Medicare or Medicaid beneficiaries, had significantly lower mean full-scale IQs.
Conclusion: On linear regression analysis, the association between the full-scale IQ, and longer duration of CKD and growth failure, remained significant after controlling for demographic and clinical variables. It is therefore necessary to investigate cognitive impairment in pediatric patients with CKD who exhibit growth failure or for a longer postmorbid period. It is believed that early interventions, such as kidney transplantation, will have a positive effect on IQ in children with CKD, as the disease negatively affects IQ due to poor glomerular filtration rate over time.
Trial Registration: ClinicalTrials.gov Identifier: NCT02165878.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144594 | PMC |
| http://dx.doi.org/10.3346/jkms.2021.36.e138 | DOI Listing |
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