AI Article Synopsis
- The study aimed to evaluate how the difficulty of thyroidectomy impacts false loss of signal (LOS) during intraoperative neuromonitoring, comparing endotracheal tube-based neuromonitoring (ETNM) and direct stimulation (pDS) signals with postoperative laryngoscopy.
- Results showed that pDS had a significantly higher positive predictive value for confirming recurrent laryngeal nerve function compared to ETNM, especially as the complexity of the thyroidectomy increased.
- ETNM exhibited higher rates of false LOS that correlated with increasing difficulty of surgery, making pDS a more reliable option in these situations.
Article Abstract
Objective: To measure the effect of thyroidectomy difficulty on intraoperative neuromonitoring false loss of signal (LOS) and to compare intraoperative endotracheal tube-based neuromonitoring (ETNM) and Checkpoint palpation-based direct stimulation (pDS) signals with postoperative laryngoscopy. We hypothesized that pDS has higher a positive predictive value for postdissection confirmation of recurrent laryngeal nerve function than ETNM and that this difference is accentuated with increasing thyroidectomy difficulty.
Study Design: Prospective single-arm cross-sectional study comparing ETNM and pDS for patients undergoing hemi-, total, or completion thyroidectomy from July 2018 to March 2020.
Setting: Single-surgeon series at a tertiary care hospital.
Methods: Percentage concordance and positive and negative predictive values were measured. Each thyroidectomy was assigned a validated thyroidectomy difficulty score, and recorded recurrent laryngeal nerve signals were compared with postoperative vocal fold mobility.
Results: Percentage concordance was 90.09%. Positive and negative predictive values were 0.19 (95% CI, 0.09-0.31) and 1.0 for ETNM and 0.59 (95% CI, 0.35-0.82) and 1.0 for pDS. The difference in positive predictive value was significant (0.40 [95% CI, 0.33-0.47], < .001). False LOS rates for ETNM and pDS were 13.19% versus 3.30% (9.89% [95% CI, 1.80%-18.62%], = .0155), 44.11% versus 0% (44.11% [95% CI, 25.80%-60.54%], < .001), and 73.33% versus 13.33% (60% [95% CI, 24.76%-78.46%], = .001) for the second through fourth thyroidectomy difficulty score quartiles, respectively. False LOS with ETNM was linearly correlated with increasing difficulty ( = 0.97).
Conclusion: ETNM was subject to high rates of postdissection false LOS that increased with thyroidectomy difficulty score. pDS is a reliable alternative that has higher positive predictive value than ETNM, particularly in more challenging cases such as those with posteriorly fixed thyroid cancers and fibrotic glands.
Evidence Level: 2.
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