AI Article Synopsis
- Researchers explored miRNA changes in healthy human placentae during pregnancy to help use them as biomarkers later on.
- They analyzed the miRNome in both the first and third trimesters, identifying 801 expressed miRNAs, with 182 remaining stable and 180 showing significant changes across gestation.
- The study highlights specific miRNA clusters on chromosomes 14, 19, and 13 that vary in expression, providing a detailed resource for future investigation into pregnancy-related epigenetic differences.
Article Abstract
To understand miRNA changes across gestation in healthy human placentae. This is essential before miRNAs can be used as biomarkers or prognostic indicators during pregnancy. Using next-generation sequencing, we characterize the normative human placenta miRNome in first (n = 113) and third trimester (n = 47). There are 801 miRNAs expressed in both first and third trimester, including 182 with similar expression across gestation (p ≥ 0.05, fold change ≤2) and 180 significantly different (false discovery rate <0.05, fold change >2). Of placenta-specific miRNA clusters, chromosome 14 miRNA cluster decreases across gestation and chromosome 19 miRNA cluster is overall highly expressed. Chromosome 13 clusters are upregulated in first trimester. This work provides a rich atlas of healthy pregnancies to direct functional studies investigating the epigenetic differences in first and third trimester placentae.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244582 | PMC |
| http://dx.doi.org/10.2217/epi-2021-0055 | DOI Listing |
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