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Safety and Efficacy of Baricitinib, Upadacitinib, and Sarilumab Implementation in Moderately-to-Severely Active Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Current Evidence.
Cureus
December 2024
Department of Anesthesiology and Intensive Care, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GRC.
This study aims to assess the efficacy and safety of newly approved Janus kinase (JAK) and interleukin-6 (IL-6) inhibitors in patients with moderately-to-severely active rheumatoid arthritis (RA) with inadequate response to or intolerance of conventional disease-modifying antirheumatic drugs. We conducted a systematic review and meta-analysis of all placebo-controlled randomized trials assessing baricitinib, sarilumab, and upadacitinib treatment in RA, published in PubMed and CENTRAL (Cochrane Central Register of Controlled Trials) databases up to October 2023. The study outcomes involved the American College of Rheumatology (ACR) 20%, 50%, and 70% responses, Health Assessment Questionnaire-Disability Index (HAQ-DI), Disease Activity Score in 28 joints (DAS28), serious adverse events, and adverse events leading to drug discontinuation.
View Article and Find Full Text PDFCorrelation of Dental and Periodontal Status With HIV Presence and Initial CD4 Counts: An Albanian Prospective Observational Study.
Cureus
December 2024
Infectious Diseases, Faculty of Medicine, University of Medicine, Tirana, ALB.
Background Different pathologies are encountered more often in human immunodeficiency virus (HIV)-infected patients, such as bacterial, fungal, viral infection, and neoplastic diseases. Recently, studies have shown that HIV-infected individuals have poorer oral health outcomes, worse dentition, and aggressive forms of periodontitis. This study aims to investigate the dental and periodontal status of HIV-infected patients, the correlation between CD4+ level and the CD4 percentage with dentition, and periodontal status.
View Article and Find Full Text PDFPulmonary Actinomycosis Induced by Total Gastrectomy and Heavy Alcohol Drinking: A Case Report.
Cureus
December 2024
Department of Oral Medicine, Nihon University School of Dentistry, Tokyo, JPN.
Combined risk factors such as total gastrectomy, heavy alcohol consumption, smoking, and poor oral hygiene may contribute to the development of pulmonary actinomycosis. Here, we present a rare case of pulmonary actinomycosis triggered by total gastrectomy and heavy alcohol consumption. The patient presented with hemoptysis and a suspected lung mass.
View Article and Find Full Text PDFTrachoma in Sudan: Risk Factors and Clinical Stages in Patients From Two Eye Care Hospitals, 2015.
Cureus
December 2024
Community Medicine, Faculty of Medicine, University of Khartoum, Khartoum, SDN.
Background Trachoma is a leading infectious cause of blindness globally. While it has largely been eliminated in developed countries, it remains endemic in many developing regions. This study aimed to examine the clinical stages of trachoma and identify common sociodemographic and household characteristics associated with the disease among patients in Sudan.
View Article and Find Full Text PDFOral health care in older people in long-term care facilities: An updated systematic review and meta-analyses of implementation strategies.
Int J Nurs Stud Adv
June 2025
Research Group Healthy Ageing, Allied Health Care and Nursing and FAITH Research, Hanze University of Applied Sciences, Petrus Driessenstraat 3, 9714, CA, Groningen, The Netherlands.
Introduction: Oral health care of older people in long-term care facilities is insufficient, stressing the need for clear evidence-based implementation strategies to improve oral care. In 2013, a systematic review was performed and new evidence was published. This study aimed to gain insights into implementation strategies used to promote or improve oral health care for older people in long-term care facilities, explore their effectiveness and uncover strategy content in behavioral change techniques, and report the differences between the current results and those of the 2013 study.
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