AI Article Synopsis
- The study investigates the molecular pathophysiology of COVID-19, focusing on how changes in plasma proteins can provide insights into the disease's severity.
- Researchers identified key differentially expressed proteins in the plasma of patients with fatal COVID-19 and used the STRING database to analyze their interactions.
- The findings highlight fibrinogen-related proteins as critical targets, suggesting that dysregulation of fibrinogen may significantly influence COVID-19 mortality.
Article Abstract
Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study.
Methods: Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing.
Results: Queried and added proteins were included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process.
Conclusions: It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126351 | PMC |
| http://dx.doi.org/10.22037/aaem.v9i1.1128 | DOI Listing |
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