Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 (mTORC1) axis, and proposed that co-targeting mTORC1 and ferroptosis is a promising strategy for cancer therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128196 | PMC |
| http://dx.doi.org/10.1080/23723556.2021.1919006 | DOI Listing |
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