AI Article Synopsis
- Most individuals with Down syndrome typically show signs of Alzheimer's disease by age 40 and develop dementia by age 60.
- The study investigated how the connectivity within the default mode network (DMN) is affected in cognitively stable adults with Down syndrome, using functional MRI scans.
- Findings indicated altered connectivity patterns within the DMN, suggesting a potential link to accelerated aging and possible early signs of Alzheimer's in individuals with Down syndrome.
Article Abstract
Introduction: Most individuals with Down syndrome (DS) have the neuropathological changes of Alzheimer's disease (AD) by age 40 and will have developed dementia by age 60. Alterations of the intrinsic connectivity of the default mode network (DMN) are associated with AD in the neurotypical population. In this study, we sought to determine whether, and how, connectivity between the hubs of the DMN were altered in cognitively stable adults with DS who did not have evidence of either mild cognitive impairment or AD.
Methods: Resting state functional MRI scans were collected from 26 healthy adults with DS and 26 healthy age-matched non-DS controls. Nodes comprising the DMN were generated as ROI's (regions of interest) and inter-nodal correlations estimated.
Results: Analysis of intra-network connectivity of the DMN revealed anterior-posterior DMN dissociation and hyper- and hypo-connectivity, suggesting "accelerated aging" in DS.
Discussion: Disruption of the DMN may serve as a prelude for AD in DS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136300 | PMC |
| http://dx.doi.org/10.1002/dad2.12105 | DOI Listing |
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