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Effectiveness of betahistine as an add-on therapy to epley maneuver for benign paroxysmal positional vertigo: A systematic review and meta-analysis.
World J Otorhinolaryngol Head Neck Surg
March 2025
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, King Abdulaziz Medical City Ministry of National Guard Health Affairs Riyadh Saudi Arabia.
Objective: Epley maneuver is the most effective treatment for benign paroxysmal positional vertigo (BPPV). Betahistine has been shown to be effective in treating BPPV. This systematic review aims to compare the effectiveness of Epley maneuver with betahistine to Epley maneuver alone in reducing residual dizziness in BPPV.
View Article and Find Full Text PDFSomatic mutations in Brazilian patients with paroxysmal nocturnal hemoglobinuria: a comprehensive analysis.
Front Med (Lausanne)
February 2025
Department of Hematology, Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil.
Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disease characterized by acquired abnormalities in the phosphatidylinositol glycan class A () gene.
Methods: This study analyzed gene using polymerase chain reaction (PCR) followed by Sanger sequencing of 31 Brazilian patients with PNH, including 23 with classical PNH and 8 with subclinical PNH (aplastic anemia and a PNH clone).
Results: A diverse spectrum of acquired variants was identified, encompassing insertions, deletions, and single-base substitutions.
Sex differences in dizziness diagnoses across acute and chronic neurological settings.
Neurol Sci
March 2025
Department of Clinical and Movement Neurosciences, University College London, London, UK.
Background & Objective: Dizziness is commoner in females and therefore clinical diagnostic frameworks are perhaps biased towards this gender. This study specifically aimed to analyse the distribution of diagnoses in neuro-otology clinics based on sex, and across age.
Methods: Retrospective cohort study based on a case note review of 474 adult patients (≥ 18 years) using electronic healthcare records from patients who were referred with a primary complaint of dizziness, vertigo, or unsteadiness in outpatient neurological clinics from January 2023 to September 2024 at University College London Hospitals, UK.
[Clinical features of benign paroxysmal positional vertigo in children].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
March 2025
To explore relevant factors to accurately diagnose BPPV in vertigo children. A retrospective study was conducted on the proportion of BPPV in children（<18 years） with vertigo who visited the Hearing and Vertigo Diagnosis and Treatment Center of Tianjin Medical University General Hospital from September 2017 to August 2023. The clinical characteristics of BPPV children, including general demographics, medical history, first visit department, comorbidities, canal involvement, response to treatment, and incidence of recurrence, were analyzed.
View Article and Find Full Text PDFNavigating the Diagnostic Challenges of Posterior Circulation Ischaemic Strokes: A Case Report of Delayed Diagnosis.
Cureus
February 2025
Department of Stroke Medicine, University Hospitals Dorset NHS Foundation Trust, Bournemouth, GBR.
Posterior circulation infarcts (POCI) can present with non-specific symptoms, making diagnosis challenging and often delayed. We present a 58-year-old lady with a history of migraine who attended the emergency department of a district general hospital with sudden onset of vertigo, nausea, and vomiting but without focal neurological deficits. At the initial assessment, she experienced marked dizziness, which was worse on opening her eyes.
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