Introduction: The traditional clinical treatment of long segmental bone defects usually requires multiple operations and depends on donor availability. The 3D bio-printing technology constitutes a great potential therapeutic tool for such an injury. However, 3D bio-printing remains a major challenge.
Objectives: In this study, we report the repair of long segmental bone defects by 3D bio-printing using a robotic manipulator 3D printer in a swine model.
Methods: We systematically optimized bio-ink gelation under physiological conditions to achieve desirable mechanical properties suitable for bone regeneration, and a D-H kinematic model was used to improve printing accuracy to 0.5 mm.
Results: These technical improvements allowed the repair of long segmental defects generated on the right tibia of pigs using 3D bio-printing within 12 min. The 3D bio-printing group showed improved treatment effects after 3 months.
Conclusion: These findings indicated that robotic 3D bio-printing is promising for direct clinical application.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132211 | PMC |
http://dx.doi.org/10.1016/j.jare.2020.11.011 | DOI Listing |
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