AI Article Synopsis
- A patient had a specific genetic condition that caused high levels of hepcidin, a protein that regulates iron in the body.
- Even though their iron levels were normal, they had a lot of inflammation in their body.
- This situation showed that without a functioning HFE gene, inflammation can still increase hepcidin levels through a different pathway in the body.
Article Abstract
We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134951 | PMC |
| http://dx.doi.org/10.1002/ccr3.4114 | DOI Listing |
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