Negative pressure wound therapy (NPWT) with instillation therapy (V.A.C. Vera-Flow™) and dwell time (NPWTi-d) is an innovative method for complex wound healing. NPWTi-d combines vacuum-aided drainage of wounds with the precise distribution of topical cleansing solution over the wounds. Furthermore, super oxidized solutions have illustrated their ability to potentiate wound healing and decrease bacterial contamination. Furthermore, aided with this method, infected wounds can be disinfected. If surgical debridement or removal of the infected site is not possible or desired. Therefore, in the case of a 66-year-old patient with diabetic foot syndrome (DFS) with severe infection, our approach was to couple NPWTi-d with instillation and dwelling of super oxidized solution to bolster benefits. This is the first case report using NPWTi-d with instillation of super oxidized solution in DFS in Switzerland. This case indicates that this approach is beneficial in the treatment of complex and critically infected wounds in DFS.
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http://dx.doi.org/10.1093/jscr/rjab167 | DOI Listing |
Int J Biol Macromol
January 2025
College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China. Electronic address:
In recent years, conductive gel materials have attracted extensive attention in the field of flexible electronics because of their excellent elasticity. When constructed as gel fibers, they can adapt to greater deformation, be woven, and be assembled with fabrics to make wearable smart devices without compromising comfort. However, gel fibers reported often exhibit insufficient mechanical properties and poor adaptability to different environment.
View Article and Find Full Text PDFSci Adv
January 2025
Institut für Biologie und Biotechnologie der Pflanzen, Universität Münster, Münster, Germany.
Systemic signaling is an essential hallmark of multicellular life. Pathogen encounter occurs locally but triggers organ-scale and organismic immune responses. In plants, elicitor perception provokes systemically expanding Ca and HO signals conferring immunity.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Winterthurerstrasse 190, Zurich, 8057, Switzerland.
Efficient drug delivery remains a significant challenge in modern medicine and pharmaceutical research. Micrometer-scale robots have recently emerged as a promising solution to enhance the precision of drug administration through remotely controlled navigation within microvascular networks. Real-time tracking is crucial for accurate guidance and confirmation of target arrival.
View Article and Find Full Text PDFJ Inorg Biochem
January 2025
Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore 641 021, India; Centre for Material Chemistry, Karpagam Academy of Higher Education (Deemed to be University), Coimbatore 641 021, India. Electronic address:
A series of new Pd(II) complexes were synthesized from the reaction of andrographolide appended hydrazide derivatives with potassium tetrachloropalladate K[PdCl]. The formation of the complexes was confirmed through structural assessments conducted using various spectroscopic techniques. From the spectral studies we confirmed that the ligands coordinated to Pd(II) ion via amine nitrogen and enone oxygen.
View Article and Find Full Text PDFJ Trace Elem Med Biol
January 2025
Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address:
Lead (Pb) toxicity impairs the growth, yield, and biochemical traits of rice, making it essential to mitigate Pb stress in soil and restore its growth and production. This study investigated the potential of ascorbic acid-coated quantum dots (AsA-QDs) in alleviating Pb stress in two rice cultivars, Japonica (JP-5) and Indica (Super Basmati), grown in pots under Pb stress (50 mg/kg as lead chloride) with AsA-QD suspensions (50 ppm and 100 ppm) as treatments. The synthesized AsA-QDs were characterized by zeta potential (-14.
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