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| http://dx.doi.org/10.5114/aoms/133361 | DOI Listing |
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Thermosensitive, injectable, antibacterial glabridin liposome/chitosan dual network hydrogel for diabetic wound healing.
Int J Biol Macromol
December 2024
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China; Department of Traditional Chinese Medicine, Institute of Guangdong Geriatric, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Thermosensitive hydrogels show great potential in healing diabetic wounds, but they are still challenged by the long healing time, risk of infectivity, and accumulation of melanin. Herein, a dual network hydrogel is designed, which consists of chlorogenic acid (CA) modified chitosan (CS) (CA@CS), poly(N-isopropylacrylamide) (PNIPAm), and glabridin liposomes (GL). The gelation transition temperature of the hydrogel is 32-34 °C, which thus endows it with superior injectability at ambient temperature.
View Article and Find Full Text PDFLab-grown, 3D Extracellular Matrix Particles Improve Cardiac Function and Morphology in Myocardial Ischemia.
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Cardiovascular Research Center, Rhode Island Hospital, Providence, RI.
The promise of injection of extracellular matrix (ECM) from animal hearts as a treatment of myocardial ischemia has been limited by immune reactions and harsh ECM-damaging extraction procedures. We developed a novel method to produce lab-grown human 3D acellular ECM particles from human mesenchymal stem cells (MSCs) to mitigate product variability, immunogenicity, and preserve ECM architecture. We hypothesized that intramyocardial injection (I/M) of this novel ECM (dia ~200 microns) would improve cardiac function in a post-myocardial infarction (MI) murine model.
View Article and Find Full Text PDFParaoxonase-1 Is a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation Through Adipose Stem Cell-Derived Extracellular Vesicles.
Int J Mol Sci
November 2024
Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan 50612, Republic of Korea.
Although adipose stem cell (ASC)-derived extracellular vesicles (EVs) are as effective as ASCs in the suppression of Th2 cell-mediated eosinophilic inflammation, the role of identified pulmonary genes has not been well documented. Thus, we assessed the immunomodulatory effects of paraoxonase-1 (PON1) on allergic airway inflammation in a mouse model of asthma. Five-week-old female C57BL/6 mice were sensitized to ovalbumin (OVA) by intraperitoneal injection and challenged intranasally with OVA.
View Article and Find Full Text PDFHUC-MSCs combined with platelet lysate treat diabetic chronic cutaneous ulcers in Bama miniature pig.
Regen Ther
June 2024
Department of Endocrinology & Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Article Synopsis
- Human umbilical cord mesenchymal stem cells (HUC-MSCs) combined with platelet lysate (PL) demonstrate significant potential for improving wound healing, especially in diabetic conditions.
- The study involved both in vitro and in vivo experiments, using high glucose cultured cells to simulate diabetic chronic ulcers and treating created wounds in pigs with various combinations of PL and HUC-MSCs.
- Results showed that the PL + HUC-MSCs treatment achieved the best healing outcomes by enhancing collagen formation, neovascularization, and regulating inflammation-related factors compared to the other treatment groups.
Sappanone A Ameliorates Concanavalin A-induced Immune-Mediated Liver Injury by Regulating M1 Macrophage Polarization.
Inflammation
November 2024
Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong, China.
Sappanone A (SAP), a high-isoflavone compound derived from the traditional Chinese medicine Sumu, exhibits various pharmacological activities, including anti-inflammatory and anti-oxidant effects. However, its protective effects on the liver have rarely been reported. The aim of this study was to investigate the effects of SAP on immune-mediated liver injury induced by concanavalin A (Con A) in mice and to explore the underlying molecular mechanisms.
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