Could amantadine interfere with COVID-19 vaccines based on the LNP-mRNA platform?

Introduction: Amantadine is a well-known medication with indications in neurology and infectious diseases. It is currently FDA approved for Parkinson's disease, drug-induced extrapyramidal symptoms, and influenza.

Methods: The article is the author's original research hypothesis.

Results: Because more people are going to be vaccinated and additional similar vaccines are going to be introduced, we should take into consideration the potential of amantadine to interfere with LNP-mRNA COVID-19 vaccine delivery into the target cells.

Conclusions: A more cautious approach to the patients taking amantadine as far as vaccination utilizing LNP-mRNA platform should be considered.