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Reimagining psychosis prevention: responding to the accessibility issues of At-Risk Mental State (ARMS) services through a selective public health approach.
BJPsych Bull
January 2025
Institute of Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
At-Risk Mental State (ARMS) services aim to prevent the onset of first-episode psychosis (FEP) in those with specific clinical or genetic risk markers. In England, ARMS services are currently expanding, but the accessibility of this preventative approach remains questionable, especially for a subgroup of FEP patients and those from specific ethnic minority communities. This commentary outlines the key debates about why a complimentary approach to psychosis prevention is necessary, and gives details for an innovative public health strategy, drawing on existing research and health prevention theory.
View Article and Find Full Text PDFCommentary on "Clinical and genetic features of childhood-onset congenital combined pituitary hormone deficiency: a retrospective, single-center cohort study".
Ann Pediatr Endocrinol Metab
December 2024
Department of Pediatrics, Jeonbuk National University Medical School, Jeonju, Korea.
Late-onset epilepsy and neurodegeneration: intersecting mechanisms or separate entities?
Brain
January 2025
Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, 8091 Zurich, Switzerland.
Molecular insights unlocking therapeutic potential for multiple myeloma and bone disease management.
J Exp Clin Cancer Res
December 2024
Department of Health Sciences, Magna Graecia University of Catanzaro, 88100, Catanzaro, Italy.
Multiple myeloma (MM), a hematologic malignancy characterized by the clonal expansion of plasma cells within the bone marrow, is associated with severe health complications, including osteolytic bone lesions that significantly increase the risk of fractures, leading to higher morbidity and mortality rates. One intriguing protein in this context is the RNA polymerase binding factor Che-1/AATF (Che-1), which has emerged as a potential player in the survival and proliferation of myeloma cells. Hippo pathway has been shown to be an important mediator of oncogenesis in solid tumors, especially for its role in shaping a tumor microenvironment favorable to cancer maintenance and spread.
View Article and Find Full Text PDFAn unstable distal radioulnar joint can cause ulnar-sided wrist pain. Stability of the distal radioulnar joint, which varies among individuals, is dependent on the bony structure of the sigmoid notch and the surrounding soft tissues, such as the interosseous membrane, the extensor carpi ulnaris tendon, the pronator quadratus, and the deep radioulnar ligaments. In particular, avulsions of the deep radioulnar ligaments lead to instability and disturbed wrist proprioception.
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