The science of toxicology dates back almost to the beginning of human history. Toxic chemicals, which are encountered in different forms, are always among the chemicals that should be investigated in criminal field, environmental application, pharmaceutic, and even industry, where many researches have been carried out studies for years. Almost all of not only drugs but also industrial dyes have toxic side and direct effects. Environmental micropollutants accumulate in the tissues of all living things, especially plants, and show short- or long-term toxic symptoms. Chemicals in forensic science can be known by detecting the effect they cause to the body with the similar mechanism. It is clear that the best tracking tool among analysis methods is molecularly printed polymer-based analytical setups. Different polymeric combinations of molecularly imprinted polymers allow further study on detection or extraction using chromatographic and spectroscopic instruments. In particular, methods used in forensic medicine can detect trace amounts of poison or biological residues on the scene. Molecularly imprinted polymers are still in their infancy and have many variables that need to be developed. In this review, we summarized how molecular imprinted polymers and toxicology intersect and what has been done about molecular imprinted polymers in toxicology by looking at the studies conducted in the last 5 years.
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http://dx.doi.org/10.1007/s11356-021-14510-4 | DOI Listing |
Mater Horiz
January 2025
Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081, Ulm, Germany.
This work involves the preparation of dual surrogate-imprinted polymers (D-MIPs) for the capture of SARS-CoV-2. To achieve this goal, an innovative and novel dual imprinting approach using carboxylated-polystyrene (PS-COOH) nanoparticles with a diameter of 100 nm and a SARS-CoV-2 Spike-derived peptide was carried out at the surface of amine-functionalized silica (PS-NH) microspheres with a diameter of 500 nm. Firstly, PS-COOH nanoparticles with the same size and spherical shape as the SARS-CoV-2 virus were employed to form hemispherical indentations (HI) at the surface of the PS-NH microspheres (obtaining dummy particle-imprinted polymers, HI-MIPs).
View Article and Find Full Text PDFJ Sep Sci
January 2025
School of Chemistry and Environment, Southwest Minzu University, Chengdu, China.
Monomer compounds from natural products are the major source of active pharmaceutical molecules, which provide great opportunities for discovering of new drugs. However, natural products contain a large number of rather complex compounds. It is difficult to obtain high-purity monomer compounds from complex natural products.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Key Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China. Electronic address:
Molecularly imprinted polymers (MIPs) are typically synthesized in organic solvents, leading to poor compatibility with water, weak affinity and selectivity for target molecules in aqueous media. To address these challenges, a green and sustainable synthesis of sandwich bread-like ATP@MIP was conducted using polyethylenimide (PEI) and deep eutectic solvent (DES) as hydrophilic bi-functional monomers via layer-by-layer self-assembly on the attapulgite (ATP) carrier. The new ATP@MIP can provide a higher density of imprinting sites with more orderly and uniform distribution due to inhibiting the competitive polymerization between PEI and DES, thereby significantly enhancing recognition ability.
View Article and Find Full Text PDFTalanta
January 2025
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
Oxidized low-density lipoprotein (oxLDL) is the leading cause of atherosclerosis and cardiovascular disease development. An enzyme-linked immunosorbent assay (ELISA)-mimic system for sensitive and specific oxLDL determination was developed using selective aptamer-molecularly imprinted polymer nanoparticles (AP-MIP NP) coupled with an immunology-based colorimetric assay. The AP-MIP NP were synthesized using solid-phase molecular imprinting by incorporating aptamers into the MIP NP cavities.
View Article and Find Full Text PDFACS Omega
January 2025
Department of Chemistry, Faculty of Science, Hacettepe University, Beytepe, Ankara 06800, Turkey.
The sensitive Bisphenol A (BPA) detection by an electrochemical sensor based on gold nanoparticle-doped molecularly imprinted polymer was successfully improved. This study describes the development of a method for BPA detection in both aqueous solution and real water samples using N-methacroyl-(L)-cysteine methyl ester and N-methacryloyl-(L)-phenylalanine methyl ester coated pencil graphite electrodes modified with AuNPs by differential pulse voltammetry (DPV). Importantly, AuNPs, which increase the electroactivity, were used to increase the surface area of a BPA-imprinted pencil graphite electrode (MIP PGE) sensor.
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