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Asymmetric bis(oxazoline)-Ni(II) catalyzed α-hydroxylation of cyclic β-keto esters under visible light. | LitMetric
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Asymmetric bis(oxazoline)-Ni(II) catalyzed α-hydroxylation of cyclic β-keto esters under visible light.

Hao Yin Chao-Jie Wang Yu-Gen Zhao Zi-Yang He Ming-Ming Chu Yi-Feng Wang Dan-Qian Xu

Org Biomol Chem

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China.

Published: August 2021

Using visible light as a driving force and molecular oxygen as a green oxidant, we developed bis(oxazoline)-Ni(acac)2 catalyzed asymmetric α-hydroxylation of β-keto esters under low photosensitizer loading, and the protocol enabled an efficient transformation to provide the desired chiral α-hydroxy-β-keto esters in high yields (up to 99%) and enantioselectivities (up to 99% ee) at room temperature.

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 Source
http://dx.doi.org/10.1039/d1ob00546dDOI Listing

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