Background: Volumetric capnography allows for continuous monitoring of expired tidal volume and carbon dioxide. The slope of the alveolar plateau of the capnogram (S) could provide information regarding ventilation homogeneity. We aimed to assess the feasibility of measuring S during newborn resuscitation and determine if S decreased after surfactant indicating ventilation inhomogeneity improvement.
Methods: Respiratory function traces of preterm infants resuscitated at birth were analysed. Ten capnograms were constructed for each infant: five pre- and post-surfactant. If a plateau was present S was calculated by regression analysis.
Results: Thirty-six infants were included, median gestational age of 28.7 weeks and birth weight of 1055 g. Average time between pre- and post-surfactant was 3.2 min. Three hundred and sixty capnograms (180 pre and post) were evaluated. There was adequate slope in 134 (74.4%) capnograms pre and in 100 (55.6%) capnograms post-surfactant (p = 0.004). Normalised for tidal volume S pre-surfactant was 18.89 mmHg and post-surfactant was 24.86 mmHg (p = 0.006). An increase in S produced an up-slanting appearance to the plateau indicating regional obstruction.
Conclusion: It was feasible to evaluate the alveolar plateau pre-surfactant in preterm infants. Ventilation inhomogeneity increased post-surfactant likely due to airway obstruction caused by liquid surfactant present in the airways.
Impact: Volumetric capnography can be used to assess homogeneity of ventilation by S analysis. Ventilation inhomogeneity increased immediately post-surfactant administration during the resuscitation of preterm infants, producing a characteristic up-slanting appearance to the alveolar plateau. The best determinant of alveolar plateau presence in preterm infants was the expired tidal volume.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197760 | PMC |
| http://dx.doi.org/10.1038/s41390-021-01578-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional analysis of yak alveolar type II epithelial cells at high and low altitudes based on single-cell sequencing.
Biochim Biophys Acta Mol Cell Res
February 2025
College of Eco-Environmental Engineering, Qinghai University, Xining, Qinghai, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai, China. Electronic address:
The adaptation of lung cells to high-altitude environments represents a notable gap in our understanding of how animals cope with hypoxic conditions. Alveolar epithelial cells type II (AEC II) are crucial for lung development and repair. However, their, specific role in the adaptation of yaks to high-altitude environments remains unclear.
View Article and Find Full Text PDFProgress and perspectives on BMP9-ID1 activation of HIF-1α and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis.
Front Oncol
November 2024
Department of Hepatic Hydatidosis, Qinghai Provincial People's Hospital, Xining, China.
Article Synopsis
- Hepatic alveolar echinococcosis is a zoonotic disease prevalent in western China, especially in regions like Qinghai, Tibet, and Xinjiang.
- Research shows that neovascularization in this disease is linked to the overexpression of VEGFA and HIF-1α, which play key roles in angiogenesis.
- The article explores the potential for treating hepatic alveolar echinococcosis by targeting signaling pathways similar to those used in liver cancer therapies, focusing on the biological roles of HIF-1α, VEGFA, and the BMP9-ID1 signaling pathway.
Transcriptomic and Metabolomic Insights into Age-Related Changes in Lung Tissue of Yaks Under Highland Stress.
Int J Mol Sci
November 2024
Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
As an indigenous species on the Tibetan Plateau, the yak is well adapted to the plateau hypoxic environment. The high-altitude hypoxia adaptation of the yak requires the adaptive reshaping of multiple tissues and organs, especially the lungs. To reveal the adaptive development of yak lungs under hypoxic stress at the tissue and molecular levels, we conducted histomorphological observations as well as transcriptomic and metabolomic studies of yak lungs at three ages (0.
View Article and Find Full Text PDFSupersaturated drug delivery system of albendazole salt-polymer complex for improving oral bioavailability and efficacy anti-secondary E. multilocularis.
Acta Trop
December 2024
Medical College, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Based on the supersaturation theory, this study devised two albendazole (ABZ) salt-polymer complexes that enhance the oral bioavailability and efficacy of secondary hepatic alveolar echinococcosis (HAE) in rats. Solid characteristics, microstructure, and stability of ABZ benzenesulfonate (ABZ-BSA) and ABZ methanesulfonate (ABZ-MSA) were evaluated. The equilibrium solubility and intrinsic dissolution rate of salt were measured across different pH environments to determine its potential for generating supersaturation.
View Article and Find Full Text PDFPictorial review of hepatic echinococcosis: Ultrasound imaging and differential diagnosis.
World J Gastroenterol
October 2024
Department of Medical Ultrasound, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.
Article Synopsis
- Echinococcosis is a disease caused by parasites that mainly impact the liver, with high-risk areas in western China experiencing significant cases of hepatic echinococcosis and hepatic alveolar echinococcosis (HAE).
- The World Health Organization recommends ultrasonography for initial screening, but there's a challenge in distinguishing between different types of liver lesions, including various types of echinococcosis.
- This review advocates for using contrast-enhanced ultrasound to improve diagnostic accuracy and discusses imaging features to aid in early diagnosis and clinical decisions in regions where the disease is prevalent.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!