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Trajectories of cognitive performance over five years in a prospective cohort of patients with breast cancer (NEON-BC). | LitMetric

Trajectories of cognitive performance over five years in a prospective cohort of patients with breast cancer (NEON-BC).

Breast

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, 135, 4050-600, Porto, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Rua das Taipas, 135, 4050-600, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal. Electronic address:

Published: August 2021

AI Article Synopsis

  • The study aimed to track cognitive performance over five years in breast cancer patients and to identify factors predicting changes in cognition.
  • It involved 464 women evaluated at multiple points using the Montreal Cognitive Assessment (MoCA) to categorize their cognitive trajectories into stable and declining groups.
  • The findings revealed four distinct cognitive performance groups, highlighting the early assessment's importance in predicting long-term cognitive decline.

Article Abstract

Purpose: To identify trajectories of cognitive performance up to five years since diagnosis and their predictors, in a cohort of patients with breast cancer (BCa).

Methods: A total of 464 women with BCa admitted to the Portuguese Institute of Oncology, Porto, during 2012, were evaluated with the Montreal Cognitive Assessment (MoCA) before any treatment, and after one, three and five years. Probable cognitive impairment (PCI) at baseline was defined based on normative age- and education-specific reference values. Mclust was used to define MoCA trajectories. Receiver Operating Characteristic curves were used to assess the predictive accuracy for cognitive trajectories.

Results: Two trajectories were identified, one with higher scores and increasing overtime, and the other, including 25.9% of the participants, showing a continuous decline. To further characterize each trajectory, participants were also classified as scoring above or below the median baseline MoCA scores. This resulted in four groups: 1) highest baseline scores, stable overtime (0.0% with PCI); 2) lowest baseline scores (29.5% with PCI); 3) mid-range scores at baseline, increasing overtime (10.5% with PCI); 4) mid-range scores at baseline, decreasing overtime (0.0% with PCI). Adding the change in MoCA during the first year to baseline variables significantly increased the accuracy to predict the downward trajectory (area under the curve [AUC] = 0.732 vs. AUC = 0.841, P < 0.001).

Conclusion: Four groups of patients with BCa with different cognitive performance trends were identified. The assessment of cognitive performance before treatments and after one year allows for the identification of patients more likely to have cognitive decline in the long term.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165446PMC
http://dx.doi.org/10.1016/j.breast.2021.05.006DOI Listing

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