Edible mushrooms have been increasingly introduced into the human diet, which has driven research into their functional properties. Thus, Agaricus brasiliensis Murill or Agaricus blazei Murill (ABM) is a species native to the Brazilian biome, whose fruiting body has been used not only for dietary purposes, but also in the development of functional foods or as source of molecules of pharmacological interest. The bioactivity of ABM has been related to the presence of polysaccharides, although the contribution of other metabolites cannot be discharged. This work describes the polysaccharides isolation methodology and preparation of the extracts of ABM and their biological activities. Furthermore, it presents a general outline of its characterizations regarding composition, chemical structure and properties in solution. The ABM and its chemical constituents exhibit several biological activities that support their potential use for prevention or treatment of diseases with inflammatory background, such as cancer, diabetes and atherosclerosis. The mechanism of action of the extracts and polysaccharides from ABM is mainly related to a modulation of immune system response or reduction of inflammatory response. This review shows that the ABM has great potential in the pharmaceutical, biotechnological and food sectors that deserves additional research using standardized products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2021.05.112 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles.
Biometals
November 2024
Department of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil.
Article Synopsis
- * The study involved synthesizing CuO nanoparticles, which were characterized for their properties and morphology, and then coated with Agaricus blazei Murill polysaccharides to improve stability and reduce toxicity.
- * The resulting coated nanoparticles demonstrated antifungal activity against Candida infections and lower toxicity in adult zebrafish, suggesting they could be promising candidates for topical treatments in medical applications.
Effect of Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Cultivated Outdoors on Wound Healing and Maintaining Skin Elasticity.
Int J Med Mushrooms
September 2024
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Royal sun medicinal mushroom Agaricus brasiliensis KA21 has various beneficial pharmacological effects; however, these effects are influenced by its cultivation conditions. A. brasiliensis KA21 is rich in β-glucan, which promotes wound healing.
View Article and Find Full Text PDFLipid Fraction from as a Potential Therapeutic Agent for Lethal Sepsis in Mice.
Antioxidants (Basel)
July 2024
Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Pará, Pará 66075-110, Brazil.
Sepsis is a potentially fatal clinical condition that results from an immune imbalance in the host during an infection. It presents systemic alterations due to excessive activation of pro-inflammatory mediators that contribute to inflammation, formation of reactive species, and tissue damage. Anti-inflammatory mediators are then extensively activated to regulate this process, leading to immune exhaustion and, consequently, immunosuppression of the host.
View Article and Find Full Text PDFEffects of Outdoor-Grown Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Fruiting Body on Canine Malassezia Dermatitis.
Int J Med Mushrooms
May 2024
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Brazil-grown outdoor-cultivated Agaricus brasiliensis KA21 fruiting body (KA21) significantly increases the production of serum anti-beta-glucan antibody. Therefore, KA21 ingestion may be useful for the prevention and alleviation of fungal infections. This study aimed to determine the effects of KA21 in fungal infections in animals.
View Article and Find Full Text PDFGC/MS and 2D NMR-based approach to evaluate the chemical profile of hydroalcoholic extract from Agaricus blazei Murill and its anti-inflammatory effect on human neutrophils.
J Ethnopharmacol
March 2024
Laboratório de Polímeros e Inovação de Materiais, Centro de Ciências, Departamento de Química Orgânica e Inorgânica, Universidade Federal Do Ceará, Campus Do Pici, Fortaleza, CEP: 60440-900, Brazil. Electronic address:
Ethnopharmacological Relevance: Agaricus blazei Murill (AbM) is one of the main mushrooms used for medicinal purposes. The use of AbM in the preparation of teas is widespread mainly in Asian countries, while in Brazil it is used as a functional food to combat inflammatory diseases and cancer.
Aim Of The Study: The main focus of this study was the characterization of the chemical profile of the hydroalcoholic extract of Agaricus blazei Murill (AbE), as well as the evaluation of its cytotoxic and anti-inflammatory potential using human neutrophils.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!