AI Article Synopsis
- - The study focuses on developing methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to co-load paclitaxel (PTX) and etoposide (ETP) for more effective treatment of intracranial glioblastoma while addressing drug delivery limitations.
- - The nanoparticles showed improved cytotoxicity and increased cell death in glioma cell lines compared to the free drug forms, with no negative impact on blood compatibility.
- - In experiments with rats, the PTX/ETP co-loaded mPEG-PLGA NPs significantly improved median survival to 76 days and enhanced tumor reduction, as confirmed through MRI, compared to much shorter survival
Article Abstract
The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to overcome pharmacokinetics and physiological limitations and enhance therapeutic efficacy for treating intracranial glioblastoma. Both drugs were loaded into mPEG-PLGA NPs by a nano-precipitation method. The resultant NPs demonstrated an enhanced cytotoxic effect indicated by lower IC values and augmented cell apoptosis to U87 and C6 glioma cell lines compared to both free drugs. Additionally, blood compatibility assays showed that the PTX/ETP co-loaded mPEG-PLGA NPs did not induce blood hemolysis, blood clotting, or platelet aggregation. In vivo anti-glioma efficacy evaluation in rats bearingintracranialC6glioma revealed a superior anti-glioma activity for the treatment with PTX/ETP co-loaded mPEG-PLGA NPs compared to other formulations, particularly a significantly longer median survival, 76 days compared to 36 days for free PTX and 37 days for free ETP treatment, respectively, and higher tumor regression, proved by magnetic resonance imaging (MRI).
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| http://dx.doi.org/10.1016/j.ijpharm.2021.120722 | DOI Listing |
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