Early stopping of a randomised trial for efficacy: a medical, ethical and regulatory challenge.

A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Early stopping of a randomised trial for efficacy: a medical, ethical and regulatory challenge.

Arthur Darmon Gregory Ducrocq

Heart

FACT (French Alliance for Cardiovascular Trials), DHU-FIRE, Hopital Bichat-Claude Bernard, Paris, France.

Published: July 2021

Download full-text PDF
Source

http://dx.doi.org/10.1136/heartjnl-2021-318941 DOI Listing

Download full-text PDF	Source
http://dx.doi.org/10.1136/heartjnl-2021-318941	DOI Listing

Publication Analysis

Top Keywords

early stopping

stopping randomised

randomised trial

trial efficacy

efficacy medical

medical ethical

ethical regulatory

regulatory challenge

early

randomised

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!