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Comparing safety, performance and user perceptions of a patient-specific indication-based prescribing tool with current practice: a mixed methods randomised user testing study.
BMJ Qual Saf
November 2024
Director, Centre for Medication Safety and Service Quality, Imperial College Healthcare NHS Trust, London, UK.
Article Synopsis
- Medication errors are a significant issue in healthcare, leading to the development of an indication-based prescribing tool aimed at improving accuracy and efficiency in medication orders.
- The study involved 24 participants performing simulated prescribing tasks with and without this new tool, revealing that the intervention resulted in fewer errors, shorter time to prescribe, and reduced perceived workload.
- The research identified specific workflow vulnerabilities in traditional prescribing methods, alongside participant feedback that highlighted themes for improvement such as integration of guidelines and user endorsement of the new tool.
The association between glucose-dependent insulinotropic polypeptide and/or glucagon-like peptide-1 receptor agonist prescriptions and substance-related outcomes in patients with opioid and alcohol use disorders: A real-world data analysis.
Addiction
February 2025
Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA.
Aims: This study aimed to estimate the strength of association between prescriptions of glucose-dependent insulinotropic polypeptide (GIP) and/or glucagon-like peptide-1 receptor agonists (GLP-1 RA) and the incidence of opioid overdose and alcohol intoxication in patients with opioid use disorder (OUD) and alcohol use disorder (AUD), respectively. This study also aimed to compare the strength of the GIP/GLP-1 RA and substance use-outcome association among patients with comorbid type 2 diabetes and obesity.
Design: A retrospective cohort study analyzing de-identified electronic health record data from the Oracle Cerner Real-World Data.
Characteristics of Patients with COPD Initiating Budesonide/Glycopyrronium/Formoterol or Other Triple Therapies in Japan: A Real-World Healthcare Claims Database Study (MITOS-AURA).
Adv Ther
December 2024
Respiratory Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Academy House, 136 Hills Road, Cambridge, CB2 8PA, UK.
Article Synopsis
- In Japan, there are different inhaler combinations for treating chronic obstructive pulmonary disease (COPD), including single-inhaler and multiple-inhaler triple therapies, but there is limited information about how patients are actually treated in real-life scenarios.
- This study reviewed data from COPD patients in Japan from May 2018 to December 2021, categorizing them into four groups based on the triple therapy they started, including early adopters of a specific therapy and users of other available combinations.
- The findings revealed that a high percentage of patients had asthma as a comorbidity, and around 14% to 18% experienced moderate to severe exacerbations in the year before starting treatment, indicating significant healthcare resource utilization
Patient-Reported Racial and Ethnic Disparities in Patients With Ulcerative Colitis: Results From the National Health and Wellness Survey.
Crohns Colitis 360
October 2024
Division of Gastroenterology, Morehouse School of Medicine, Atlanta, GA, USA.
Background: Ulcerative colitis (UC) is an inflammatory condition characterized by chronic, disabling gastrointestinal symptoms that can have detrimental effects on psychological, social, and professional quality of life. Few studies have examined patient-reported outcomes (PROs) and economic outcomes among individuals with varying UC severity and across different racial/ethnic groups.
Methods: This cross-sectional study assessed sociodemographic data, PROs, and economic outcomes for participants from the National Health and Wellness Survey (2018, 2019, and 2020) with UC.
The Association of Heart Failure and Edema Events between Patients Initiating Sodium Zirconium Cyclosilicate or Patiromer.
Kidney360
December 2024
Cerner Enviza, Malvern, Pennsylvania.
Key Points: One previous study using claims data reported signals for higher hospitalizations for heart failures and severe edema in patients prescribed a potassium binder using sodium exchange. In this study, sodium zirconium cyclosilicate use was associated with increased risk of prespecified encounters of hospitalizations for heart failure and major edema encounters. Our findings highlight the need to weigh the benefits and risks of sodium zirconium cyclosilicate and patiromer in routine clinical practice.
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