Growing demand of Juul and other electronic cigarettes, despite critical knowledge gaps about their chemical composition, has led to concerns regarding their potential health effects. We introduce a novel analytical approach, runtime cavity ringdown spectroscopy (rtCRDS) for rapid detection of oxidative products in e-cigarette aerosols, to facilitate the study of aerosol from a single puff of e-liquid. We report a systematic investigation of three flavors of commercial Juul pods (Virginia tobacco, mango, and menthol) and known commercial e-liquid ingredients (propylene glycol (PG), vegetable glycerin (VG), nicotine, ethyl maltol, benzoic acid, and nicotine benzoate) vaped using Juul devices. Juul e-liquids and neat chemical additives spiked into a 30:70 PG/VG solution were vaped and their aerosols were collected in 1-L Tedlar gas bags and analyzed using rtCRDS. Acetaldehyde, formaldehyde, and acetone were identified as primary oxidative products in aerosolized PG/VG. Ethanol was detected as a major constituent of the three commercial Juul flavors. Spectral intensities of carbonyl compounds increased with the addition of spikes, benzoic acid, ethyl maltol, and nicotine to PG/VG, suggesting that oxidative product generation increases with common additives. The method of direct, rapid analysis of e-cig aerosols introduced here can be used to complement traditional methods in vaping exposures.
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