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Effects of gut microbiota and metabolites on the host defense peptide expression.
Appl Microbiol Biotechnol
January 2025
National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Hangzhou, 310058, Zhejiang, China.
The widespread use of antibiotics has led to the emergence of multidrug-resistant bacteria, which pose significant threats to animal health and food safety. Host defense peptides (HDPs) have emerged as promising alternatives because of their unique antimicrobial properties and minimal resistance induction. However, the high costs associated with HDP production and incorporation into animal management practices hinder their widespread application.
View Article and Find Full Text PDFPrevalence and associated factors of healthy aging among community-dwelling older adults in Lishui city, China: a cross-sectional study.
BMC Public Health
January 2025
Department of Nursing, School of Medicine, Lishui University, No. 1 Xueyuan Road, Lishui City, Zhejiang Province, 323000, China.
Background: Identifying the level of healthy aging and exploring its associated factors are prerequisites in the planning of effective measures among the elderly population. Thus, this study aimed to investigate the prevalence of healthy aging and determine its associated factors among community-dwelling older adults from mountain areas in Lishui, China.
Methods: A multicenter cross-sectional survey was conducted.
Cross-trait multivariate GWAS confirms health implications of pubertal timing.
Nat Commun
January 2025
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Pubertal timing is highly variable and is associated with long-term health outcomes. Phenotypes associated with pubertal timing include age at menarche, age at voice break, age at first facial hair and growth spurt, and pubertal timing seems to have a shared genetic architecture between the sexes. However, puberty phenotypes have primarily been assessed separately, failing to account for shared genetics, which limits the reliability of the purported health implications.
View Article and Find Full Text PDFNo significant relationship found between spontaneous motor tempo, heartbeat, and individual alpha frequency: an analysis of internal tempos.
Sci Rep
January 2025
Department of Life Sciences, The University of Tokyo, Tokyo, Japan.
Many theories of time perception propose the existence of an internal pacemaker, and studies across behavioral, physiological, and neuroscience fields have explored this concept. Specifically, Spontaneous Motor Tempo (SMT), the most comfortable and natural tapping tempo for each individual, is thought to reflect this internal pacemaker's tempo. Changes in heart rate are also linked to time estimation, while Individual Alpha Frequency (IAF), the peak in the alpha range (8-13 Hz) observed in EEG, is reported to reflect the brain's temporal processing.
View Article and Find Full Text PDFDefinition and diagnostic criteria of clinical obesity.
Lancet Diabetes Endocrinol
January 2025
Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK; Catholic University of the Sacred Heart, Rome, Italy; University Polyclinic Foundation Agostino Gemelli IRCCS, Rome, Italy.
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