Objective: To investigate the diagnostic value of quantitative parameters of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in prostate cancer.
Methods: From January 2019 to June 2020, 96 patients with prostatic tumor admitted in the department of urological surgery of our hospital were selected as subjects. Magnetic resonance imaging data of 48 cases of benign prostatic hyperplasia and 48 cases of prostate cancer were retrospectively analyzed. The patients included in this study received conventional MRI and IVIM-DWI examinations. Quantitative parameters of IVIM-DWI including D value, D* value, apparent diffusion coefficient (ADC) value and f value in lesions of prostatic tumor were calculated through the double exponential model fitting algorithm. D value, D* value, ADC value and f value were compared between benign prostatic hyperplasia (BPH) group and prostate cancer group. Quantitative parameters of IVIM-DWI were also compared among patients from different Gleason scores groups. The correlation of quantitative parameters of IVIM-DWI with Gleason scores and PSA concentration was analyzed. Diagnostic efficiency of quantitative parameters of IVIM-DWI for prostate cancer was evaluated by ROC curve.
Results: Compared with those in BPH group, D value, ADC value and f value in prostate cancer group were significantly lower, but D* value was obviously higher. With the Gleason score increased, D value, ADC value and f value gradually decreased, while D* value gradually increased. The diagnostic efficiency of parameters ADC and D was higher among other parameters. D value, ADC value and f value of prostate cancer were negatively correlated with Gleason score and PSA concentration, respectively (all P<0.05), while D* value was positively correlated with Gleason score and PSA concentration.
Conclusions: Quantitative parameters of IVIM-DWI could be used for the diagnosis and evaluation of prostate cancer, and quantitative parameters of IVIM-DWI were associated with Gleason score and PSA concentration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129261 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Application of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines.
Anal Chim Acta
May 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China. Electronic address:
Background: Herbal medicines and their preparations play a significant role in healthcare systems, yet concerns remain about their quality consistency. Chemical fingerprinting and multi-component quantitative analysis are the commonly used analytical methods and are widely applied in the quality analysis of herbal medicines. The study uses Gegen Qinlian tablets (GQTs) as a case to propose a comprehensive quality consistency evaluation system.
View Article and Find Full Text PDFModeling the impact of between-lot and within-lot variability in Listeria monocytogenes contamination on risk reduction from sampling ready-to-eat foods.
J Food Prot
March 2025
Human Foods Program, U.S. Food and Drug Administration, 5001 Campus Drive, College Park, MD 20740 USA.
Microbiological sampling and testing are widely utilized in food safety risk management. We developed risk assessments to quantify the impact of various sampling plans on the risk of invasive listeriosis to consumers. We used the FDA-iRISK® tool and adapted available process, consumption, and dose response modules of published L.
View Article and Find Full Text PDFEvaluating quality consistency of Celosiae Cristatae Flos by four dimensional fingerprints combined with antioxidant activity.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address:
Celosiae Cristatae Flos (CCF) has haemostatic and anti-dysentery properties, making it a natural medicine worthy of further development. However, there are few studies on it and most of them are based on high performance liquid chromatography. Consequently, there is a need to develop a comprehensive quality evaluation method based on multiple analytical techniques to reveal the composition of CCF.
View Article and Find Full Text PDFDetermination of hordenine in beer samples and bodybuilding supplement at the electrified liquid-liquid interface.
Food Chem
March 2025
University of Lodz, Faculty of Chemistry, Department of Inorganic and Analytical Chemistry, Electrochemistry@Soft Interface Team, Tamka 12, 91-403 Łódź, Poland.
This paper presents an electrochemical approach to quantitative and qualitative determination of hordenine (HODE) at the electrified liquid-liquid interface (eLLI). In this regard, we have employed ion transfer voltammetry (ITV) as an electroanalytical detection technique. The response of peak current values (positive or negative currents) increased linearly with HODE concentration in the studied concentration range from 28.
View Article and Find Full Text PDFModelling and classification of barriers in the construction of smart villages in developing countries.
Eval Program Plann
March 2025
Ghulam Ishaq Khan Institute of Engineering Sciences and Technology, Pakistan. Electronic address:
Smart Villages are an innovative solution for tackling global sustainability per the sustainable development goals set by the United Nations. This particular study looks into the implementation of a similar Smart Village concept in developing countries such as Pakistan. The main focus is to identify and classify a set of barriers that are to be considered while constructing a smart village.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!