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A Structured, Anatomy-Based Chest CT Interpretation Curriculum for Pulmonary Fellows Covering the Main Patterns of Parenchymal Lung Disease.
MedEdPORTAL
January 2025
Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington School of Medicine; Staff Physician, Pulmonary, Critical Care and Sleep Medicine Section, Veterans Affairs Puget Sound Healthcare System.
Introduction: Chest computed tomography (CT) interpretation is a key competency for pulmonary fellows, with many resources intended for radiologists but very few for this specific group. We endeavored to create a curriculum to teach chest CT interpretation to first-year pulmonary fellows.
Methods: We assembled a team of two pulmonologists, one radiologist, and a fellow with computer drafting software experience.
PSMA-Targeted Intracellular Self-Assembled Probe for Enhanced PET Imaging.
Bioconjug Chem
January 2025
School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China.
Positron-emission tomography (PET) offers high sensitivity for cancer diagnosis. However, small-molecule-based probes often exhibit insufficient accumulation in tumor sites, while nanoparticle-based agents typically have limited delivery efficiency. To address this challenge, this study proposes a novel PET imaging probe, Ga-CBT-PSMA, designed for prostate cancer.
View Article and Find Full Text PDFEngineering Peptide-Based Molecular Baits for Targeted Fishing and Protein Profiling of Exosomes as a Liquid Biopsy for Gastrointestinal Adenocarcinoma.
Anal Chem
January 2025
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
High-performance isolation of exosomes as a promising liquid biopsy target is of great importance for both fundamental research and clinical applications. This is, however, challenged by the prevalent heterogeneity of exosomes and the highly complex nature of biosamples. Here, we introduce the use of a CD81-targeting peptide as a building block for tailoring molecular baits for exosome isolation and payload analysis in clinical biofluids.
View Article and Find Full Text PDFStepwise order in protein complex assembly: approaches and emerging themes.
Open Biol
January 2025
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO 80045, USA.
Protein-based nanomachines drive every cellular process. An explosion of high-resolution structures of multiprotein complexes has improved our understanding of what these machines look like and how they work, but we still know relatively little about how they assemble in living cells. For example, it has only recently been appreciated that many complexes assemble co-translationally, with at least one subunit still undergoing active translation while already interacting with other subunits.
View Article and Find Full Text PDFViroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization.
Q Rev Biophys
January 2025
Instituto Biofisika (CSIC-UPV/EHU), University of the Basque Country (UPV/EHU), Bilbao, Spain.
The 'Viroporin' family comprises a number of mostly small-sized, integral membrane proteins encoded by animal and plant viruses. Despite their sequence and structural diversity, viroporins share a common functional trend: their capacity to assemble transmembrane channels during the replication cycle of the virus. Their selectivity spectrum ranges from low-pH-activated, unidirectional proton transporters, to size-limited permeating pores allowing passive diffusion of metabolites.
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