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SGLT2 inhibitors in the prevention of diabetic cardiomyopathy: Targeting the silent threat.
World J Cardiol
November 2024
Department of 1st Cardiology, Athens Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Heart failure (HF) is a major global health challenge, particularly among individuals with type 2 diabetes mellitus (T2DM), who are at significantly higher risk of developing HF. Diabetic cardiomyopathy, a unique form of heart disease, often progresses silently until advanced stages. Recent research has focused on sodium-dependent glucose transporter 2 inhibitors (SGLT2i), originally developed for hyperglycemia, which have shown potential in reducing cardiovascular risks, including HF hospitalizations, irrespective of diabetic status.
View Article and Find Full Text PDFDiabetes and obesity: A debate on bariatric interventions and its implications.
World J Diabetes
November 2024
College of Medicine, Postgraduate Program in Physiotherapy and Functionality, Department of Physiotherapy, Federal University of Ceará-UFC, Fortaleza 60430-450, Ceará, Brazil.
In this editorial, we comment on an article by Tang published in the . Obesity and diabetes are two pathological situations that are intrinsically related. Neither lifestyle changes nor pharmacological treatments have achieved diabetes remission.
View Article and Find Full Text PDFSystemic Postnatal Corticosteroids, Bronchopulmonary Dysplasia, and Survival Free of Cerebral Palsy.
JAMA Pediatr
January 2025
Departments of Obstetrics, Gynaecology, and Newborn Health, the Royal Women's Hospital, University of Melbourne, Parkville, Victoria, Australia.
Importance: Systemic postnatal corticosteroids have been shown to reduce rates of bronchopulmonary dysplasia (BPD) in infants born preterm, but both corticosteroids and BPD are associated with cerebral palsy.
Objective: To describe how the association between systemic postnatal corticosteroids and survival free of cerebral palsy varies with the risk of BPD in infants born preterm, and if the association differs between dexamethasone and hydrocortisone, or with age at starting treatment.
Design, Setting, And Participants: This comparative effectiveness research used weighted meta-regression analysis of eligible randomized clinical trials (RCTs) of systemic postnatal corticosteroids reported from June 1989 through March 2022 that included rates of all of BPD, mortality, and cerebral palsy in neonatal intensive care units in 10 countries.
Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression.
World J Clin Cases
November 2024
Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 343433, Egypt.
Article Synopsis
- * PFD is effective in managing IPF at various stages, showing antifibrotic, anti-inflammatory, and antioxidant benefits.
- * Although some patients may experience side effects and require dosage adjustments, PFD helps slow disease progression and improves overall patient outcomes, including reducing serious health events and mortality rates.
Harnessing the power of : Anti-cancer properties and Wnt pathway modulation in hepatocellular carcinoma.
World J Gastroenterol
November 2024
Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
In this manuscript, we comment on the article, which explores the anti-cancer effects of (CB) in tumor biology. We highlight its potential, particularly in hepatocellular carcinoma (HCC), where it inhibits the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways and induces apoptosis. CB contains compounds such as oleanolic acid and ursolic acid that target interleukin-6, mitogen-activated protein kinase 8, vascular endothelial growth factor, and caspase-3, offering anti-inflammatory and hepatoprotective benefits.
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