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Targeting GSK-3β for adipose dysfunction and cardiovascular complications of metabolic disease: An entangled WNT/β-catenin question.
FASEB J
December 2024
Faculty of Pharmacy, Alamein International University, Alamein, Egypt.
Individuals with metabolic syndrome have a high risk of developing cardiovascular disorders that is closely tied to visceral adipose tissue dysfunction, as well as an altered interaction between adipose tissue and the cardiovascular system. In metabolic syndrome, adipose tissue dysfunction is associated with increased hypertrophy, reduced vascularization, and hypoxia of adipocytes, leading to a pro-oxidative and pro-inflammatory environment. Among the pathways regulating adipose tissue homeostasis is the wingless-type mammary tumor virus integration site family (Wnt) signaling pathway, with both its canonical and non-canonical arms.
View Article and Find Full Text PDFExpanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models.
bioRxiv
December 2024
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Article Synopsis
- GABAergic interneurons are crucial for neural circuit function, and their dysfunction is linked to various disorders.
- A new method was developed to enhance differentiation of human pluripotent stem cells into specific GABAergic neuron types by using transcription factors and inhibiting signaling pathways.
- The study found distinct gene expression profiles in different induced neurons, highlighting their potential in disease modeling and investigation of mutations related to neurodevelopmental disorders.
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.
EMBO Mol Med
January 2025
Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium.
The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3.
View Article and Find Full Text PDFEfficacy and safety of apraglutide in short bowel syndrome with intestinal failure and colon-in-continuity: A multicenter, open-label, metabolic balance study.
Clin Nutr
December 2024
Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium; Leuven Intestinal Failure and Transplantation Center (LIFT), University Hospitals Leuven, Leuven, Belgium. Electronic address:
Article Synopsis
- Apraglutide is a new long-acting GLP-2 analog being tested for short bowel syndrome with intestinal failure (SBS-IF) in a phase 2 study.
- The study involved 9 adult patients receiving weekly injections of apraglutide over 52 weeks, measuring its safety and effects on their nutritional needs and intestinal health.
- Results showed significant improvements, including a 52% decrease in parenteral support needs and enhanced absorption of nutrients, alongside a manageable safety profile with mostly mild adverse events.
A budget impact analysis of exclusive human milk diet in very low birth weight infants in United Arab Emirates.
J Med Econ
November 2024
Dubai Health Authority, Dubai, UAE.
Introduction: Very low birth weight (VLBW) infants have the highest rate of neonatal intensive care unit (NICU) admissions owing to the higher comorbidities associated with premature birth and long hospital stays. VLBW infants fed a bovine (BOV)-based diet have higher mortality rates, necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and other comorbidities than those fed 100% human milk-based products. This study aims to evaluate the budgetary impact of adopting an exclusive human milk diet (EHMD) instead of a BOV-based diet in VLBW infants from Al-Ain Hospital, Sheikh Shakhbout Medical City, and Dubai Health Authority (DHA) in the United Arab Emirates (UAE).
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