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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">34016558</PMID><DateCompleted><Year>2022</Year><Month>03</Month><Day>01</Day></DateCompleted><DateRevised><Year>2023</Year><Month>01</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5010</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2022</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society</Title><ISOAbbreviation>J Cyst Fibros</ISOAbbreviation></Journal><ArticleTitle>Lack of CFTR alters the ferret pancreatic ductal epithelial secretome and cellular proteome: Implications for exocrine/endocrine signaling.</ArticleTitle><Pagination><StartPage>172</StartPage><EndPage>180</EndPage><MedlinePgn>172-180</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcf.2021.04.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1569-1993(21)00120-X</ELocationID><Abstract><AbstractText Label="BACKGROUND">Cystic fibrosis (CF) related diabetes is the most common comorbidity for CF patients and associated with islet dysfunction. Exocrine pancreas remodeling in CF alters the microenvironment in which islets reside. Since CFTR is mainly expressed in pancreatic ductal epithelium, we hypothesized altered CF ductal secretions could impact islet function through paracrine signals.</AbstractText><AbstractText Label="METHOD">We evaluated the secretome and cellular proteome of polarized WT and CF ferret ductal epithelia using quantitative ratiometric mass spectrometry. Differentially secreted proteins (DSPs) or expressed cellular proteins were used to mine pathways, upstream regulators and the CFTR interactome to map candidate CF-associated alterations in ductal signaling and phenotype. Candidate DSPs were evaluated for their in vivo pancreatic expression patterns and their functional impact on islet hormone secretion.</AbstractText><AbstractText Label="RESULTS">The secretome and cellular proteome of CF ductal epithelia was significantly altered relative to WT and implicated dysregulated TGF&#x3b2;, WNT, and BMP signaling pathways. Cognate receptors of DSPs from CF epithelia were equally distributed among endocrine, exocrine, and stromal pancreatic cell types. IGFBP7 was a downregulated DSP in CF ductal epithelia in vitro and exhibited reduced CF ductal expression in vivo. IGFBP7 also altered WT islet insulin secretion in response to glucose. Many CFTR-associated proteins, including SLC9A3R1, were differentially expressed in the CF cellular proteome. Upstream regulators of the differential CF ductal proteome included TGF&#x3b2;, PDX1, AKT/PTEN, and INSR signaling. Data is available via ProteomeXchange with identifier PXD025126.</AbstractText><AbstractText Label="CONCLUSION">These findings provide a proteomic roadmap for elucidating disturbances in autocrine and paracrine signals from CF pancreatic ducts and how they may alter islet function and maintenance.</AbstractText><CopyrightInformation>Copyright &#xa9; 2021. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rotti</LastName><ForeName>Pavana G</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Dept. of Anatomy and Cell Biology, The Univ. of Iowa, Iowa City, IA, USA; Dept. Biomedical Engineering, The Univ. of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>Idil A</ForeName><Initials>IA</Initials><AffiliationInfo><Affiliation>Dept. of Anatomy and Cell Biology, The Univ. of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yulong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Dept. of Anatomy and Cell Biology, The Univ. of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Dept. of Anatomy and Cell Biology, The Univ. of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunicelli</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Dept. of Anatomy and Cell Biology, The Univ. of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Malley</LastName><ForeName>Yunxia</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Stead Family Department of Pediatrics, The Univ. of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norris</LastName><ForeName>Andrew W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Stead Family Department of Pediatrics, The Univ. of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center Roy J. and Lucille A. Carver College of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uc</LastName><ForeName>Aliye</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Stead Family Department of Pediatrics, The Univ. of Iowa, Iowa City, IA, USA; Department of Radiation Oncology, The Univ. of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center Roy J. and Lucille A. Carver College of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engelhardt</LastName><ForeName>John F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Dept. of Anatomy and Cell Biology, The Univ. of Iowa, Iowa City, IA, USA; Dept. Biomedical Engineering, The Univ. of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center Roy J. and Lucille A. Carver College of Medicine. Electronic address: john-engelhardt@uiowa.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 DK054759</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK097820</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RC2 DK124207</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>05</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Cyst Fibros</MedlineTA><NlmUniqueID>101128966</NlmUniqueID><ISSNLinking>1569-1993</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C505032">CFTR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020543">Proteome</NameOfSubstance></Chemical><Chemical><RegistryNumber>126880-72-6</RegistryNumber><NameOfSubstance UI="D019005">Cystic Fibrosis Transmembrane Conductance Regulator</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003550" MajorTopicYN="N">Cystic Fibrosis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019005" MajorTopicYN="N">Cystic Fibrosis Transmembrane Conductance Regulator</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003920" MajorTopicYN="N">Diabetes Mellitus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010188" MajorTopicYN="N">Exocrine Pancreatic Insufficiency</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046790" MajorTopicYN="N">Pancreas, Exocrine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010183" MajorTopicYN="N">Pancreatic Ducts</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020543" MajorTopicYN="N">Proteome</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000089282" MajorTopicYN="N">Secretome</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cystic Fibrosis</Keyword><Keyword MajorTopicYN="N">Cystic Fibrosis Related Diabetes</Keyword><Keyword MajorTopicYN="N">ductal cells</Keyword><Keyword MajorTopicYN="N">pancreas</Keyword><Keyword MajorTopicYN="N">proteome</Keyword><Keyword MajorTopicYN="N">secretome</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare no existing conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2021</Year><Month>1</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2021</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>4</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2022</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>5</Month><Day>21</Day><Hour>5</Hour><Minute>57</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2023</Year><Month>1</Month><Day>1</Day></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">34016558</ArticleId><ArticleId IdType="mid">NIHMS1705811</ArticleId><ArticleId IdType="pmc">PMC8595456</ArticleId><ArticleId IdType="doi">10.1016/j.jcf.2021.04.010</ArticleId><ArticleId IdType="pii">S1569-1993(21)00120-X</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Elborn JS. Cystic fibrosis. Lancet. 2016;388(10059):2519&#x2013;31.</Citation><ArticleIdList><ArticleId IdType="pubmed">27140670</ArticleId></ArticleIdList></Reference><Reference><Citation>Staab D Cystic fibrosis -- therapeutic challenge in cystic fibrosis children. Eur J Endocrinol. 2004;151 Suppl 1:S77&#x2013;80.</Citation><ArticleIdList><ArticleId IdType="pubmed">15339249</ArticleId></ArticleIdList></Reference><Reference><Citation>Moran A, Dunitz J, Nathan B, Saeed A, Holme B, Thomas W. Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality. Diabetes Care. 2009;32(9):1626&#x2013;31.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC2732133</ArticleId><ArticleId IdType="pubmed">19542209</ArticleId></ArticleIdList></Reference><Reference><Citation>Norris AW, Ode KL, Merjaneh L, Sanda S, Yi Y, Sun X, et al. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. J Endocrinol. 2019.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC6675675</ArticleId><ArticleId IdType="pubmed">30759072</ArticleId></ArticleIdList></Reference><Reference><Citation>Yi Y, Norris AW, Wang K, Sun X, Uc A, Moran A, et al. Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2016;194(8):974&#x2013;80.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC5067820</ArticleId><ArticleId IdType="pubmed">27447840</ArticleId></ArticleIdList></Reference><Reference><Citation>Rotti PG, Xie W, Poudel A, Yi Y, Sun X, Tyler SR, et al. Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets. Am J Pathol. 2018;188(4):876&#x2013;90.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC5963477</ArticleId><ArticleId IdType="pubmed">29366680</ArticleId></ArticleIdList></Reference><Reference><Citation>Yi Y, Sun X, Gibson-Corley K, Xie W, Liang B, He N, et al. A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology. 2016;157(5):1852&#x2013;65.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC4870869</ArticleId><ArticleId IdType="pubmed">26862997</ArticleId></ArticleIdList></Reference><Reference><Citation>Tyler SR, Rotti PG, Sun X, Yi Y, Xie W, Winter MC, et al. PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq. Cell Rep. 2019;26(7):1951&#x2013;64 e8.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC6394844</ArticleId><ArticleId IdType="pubmed">30759402</ArticleId></ArticleIdList></Reference><Reference><Citation>Sun X, Yi Y, Xie W, Liang B, Winter MC, He N, et al. CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors. Endocrinology. 2017;158(10):3325&#x2013;38.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC5659686</ArticleId><ArticleId IdType="pubmed">28977592</ArticleId></ArticleIdList></Reference><Reference><Citation>Olivier AK, Yi Y, Sun X, Sui H, Liang B, Hu S, et al. Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. J Clin Invest. 2012;122(10):3755&#x2013;68.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3534166</ArticleId><ArticleId IdType="pubmed">22996690</ArticleId></ArticleIdList></Reference><Reference><Citation>Wilschanski M, Novak I. The cystic fibrosis of exocrine pancreas. Cold Spring Harb Perspect Med. 2013;3(5):a009746.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3633181</ArticleId><ArticleId IdType="pubmed">23637307</ArticleId></ArticleIdList></Reference><Reference><Citation>Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K. A role for SPARC in the moderation of human insulin secretion. PLoS One. 2013;8(6):e68253.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3695891</ArticleId><ArticleId IdType="pubmed">23840838</ArticleId></ArticleIdList></Reference><Reference><Citation>Pardo FN, Altirriba J, Pradas-Juni M, Garcia A, Ahlgren U, Barbera A, et al. The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice. Diabetologia. 2012;55(12):3331&#x2013;40.</Citation><ArticleIdList><ArticleId IdType="pubmed">22926403</ArticleId></ArticleIdList></Reference><Reference><Citation>Bastidas-Ponce A, Scheibner K, Lickert H, Bakhti M. Cellular and molecular mechanisms coordinating pancreas development. Development. 2017;144(16):2873&#x2013;88.</Citation><ArticleIdList><ArticleId IdType="pubmed">28811309</ArticleId></ArticleIdList></Reference><Reference><Citation>Singh AK, Riederer B, Krabbenhoft A, Rausch B, Bonhagen J, Lehmann U, et al. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest. 2009;119(3):540&#x2013;50.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC2648694</ArticleId><ArticleId IdType="pubmed">19221439</ArticleId></ArticleIdList></Reference><Reference><Citation>Rajesh K, Krishnamoorthy J, Kazimierczak U, Tenkerian C, Papadakis AI, Wang S, et al. Phosphorylation of the translation initiation factor eIF2alpha at serine 51 determines the cell fate decisions of Akt in response to oxidative stress. Cell Death Dis. 2015;6:e1591.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC4669752</ArticleId><ArticleId IdType="pubmed">25590801</ArticleId></ArticleIdList></Reference><Reference><Citation>Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, et al. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015;43(4):690&#x2013;702.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC4618086</ArticleId><ArticleId IdType="pubmed">26410627</ArticleId></ArticleIdList></Reference><Reference><Citation>Sun J, Zhang D, Bae DH, Sahni S, Jansson P, Zheng Y, et al. Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis. 2013;34(9):1943&#x2013;54.</Citation><ArticleIdList><ArticleId IdType="pubmed">23671130</ArticleId></ArticleIdList></Reference><Reference><Citation>Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, et al. A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Cell. 2019;176(4):790&#x2013;804 e13.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC6705176</ArticleId><ArticleId IdType="pubmed">30661759</ArticleId></ArticleIdList></Reference><Reference><Citation>Maestro MA, Cardalda C, Boj SF, Luco RF, Servitja JM, Ferrer J. Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth. Endocr Dev. 2007;12:33&#x2013;45.</Citation><ArticleIdList><ArticleId IdType="pubmed">17923767</ArticleId></ArticleIdList></Reference><Reference><Citation>Chen Z, Zhang D, Yue F, Zheng M, Kovacevic Z, Richardson DR. The iron chelators Dp44mT and DFO inhibit TGF-beta-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem. 2012;287(21):17016&#x2013;28.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3366822</ArticleId><ArticleId IdType="pubmed">22453918</ArticleId></ArticleIdList></Reference><Reference><Citation>Kong JS, Park JH, Yoo SA, Kim KM, Bae YJ, Park YJ, et al. Dynamic transcriptome analysis unveils key proresolving factors of chronic inflammatory arthritis. J Clin Invest. 2020;130(8):3974&#x2013;86.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC7410073</ArticleId><ArticleId IdType="pubmed">32407294</ArticleId></ArticleIdList></Reference><Reference><Citation>Lim GE, Piske M, Lulo JE, Ramshaw HS, Lopez AF, Johnson JD. Ywhaz/14&#x2013;3-3zeta Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism. Endocrinology. 2016;157(7):2649&#x2013;59.</Citation><ArticleIdList><ArticleId IdType="pubmed">27167773</ArticleId></ArticleIdList></Reference><Reference><Citation>Hu L, He F, Huang M, Zhao Q, Cheng L, Said N, et al. SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic beta cells. Sci Rep 2020;10(1):17581.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC7567887</ArticleId><ArticleId IdType="pubmed">33067534</ArticleId></ArticleIdList></Reference><Reference><Citation>Kogan I, Ramjeesingh M, Li C, Kidd JF, Wang Y, Leslie EM, et al. CFTR directly mediates nucleotide-regulated glutathione flux. EMBO J. 2003;22(9):1981&#x2013;9.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC156066</ArticleId><ArticleId IdType="pubmed">12727866</ArticleId></ArticleIdList></Reference><Reference><Citation>Valdivieso AG, Santa-Coloma TA. CFTR activity and mitochondrial function. Redox Biol. 2013;1:190&#x2013;202.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3757715</ArticleId><ArticleId IdType="pubmed">24024153</ArticleId></ArticleIdList></Reference><Reference><Citation>Favia M, de Bari L, Bobba A, Atlante A. An Intriguing Involvement of Mitochondria in Cystic Fibrosis. J Clin Med. 2019;8(11).</Citation><ArticleIdList><ArticleId IdType="pmc">PMC6912654</ArticleId><ArticleId IdType="pubmed">31698802</ArticleId></ArticleIdList></Reference><Reference><Citation>Riquelme SA, Lozano C, Moustafa AM, Liimatta K, Tomlinson KL, Britto C, et al. CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection. Sci Transl Med. 2019;11(499).</Citation><ArticleIdList><ArticleId IdType="pmc">PMC6784538</ArticleId><ArticleId IdType="pubmed">31270271</ArticleId></ArticleIdList></Reference><Reference><Citation>Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, et al. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005;8(3):185&#x2013;95.</Citation><ArticleIdList><ArticleId IdType="pubmed">16169464</ArticleId></ArticleIdList></Reference><Reference><Citation>Strubberg AM, Liu J, Walker NM, Stefanski CD, MacLeod RJ, Magness ST, et al. Cftr Modulates Wnt/beta-Catenin Signaling and Stem Cell Proliferation in Murine Intestine. Cell Mol Gastroenterol Hepatol. 2018;5(3):253&#x2013;71.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC5904038</ArticleId><ArticleId IdType="pubmed">29675451</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></PubmedArticle></PubmedArticleSet>