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Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity. | LitMetric

Preclinical models for investigating how bone marrow adipocytes influence bone and hematopoietic cellularity.

Best Pract Res Clin Endocrinol Metab

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

Published: July 2021

Laboratory mice are a crucial preclinical model system for investigating bone marrow adipocyte (BMAd)-bone and BMAd-hematopoiesis interactions. In this review, we evaluate the suitability of mice to model common human diseases related to osteopenia or hematopoietic disorders, point out consistencies and discrepancies among different studies, and provide insights into model selection. Species, age, sex, skeletal site, and treatment protocol should all be considered when designing future studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458229PMC
http://dx.doi.org/10.1016/j.beem.2021.101547DOI Listing

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