AI Article Synopsis
- The study aimed to explore the connection between skin lesions in children and SARS-CoV-2 infection, while also considering other potential infectious or autoimmune causes.
- A total of 62 children were analyzed, with 14.5% showing positive antibodies for SARS-CoV-2, but no PCR positives detected among those tested.
- Those with positive serology were more likely to exhibit specific skin manifestations like chilblains and vesicular lesions, while those without antibodies showed different types of rashes, suggesting a potential link between certain skin conditions and prior COVID-19 exposure.
Article Abstract
Background: Cutaneous manifestations have been included in COVID-19 patients' clinical spectrum. Our objective was to determine the association between skin lesions in children and SARS-CoV-2 infection, analyzing others possible infectious/autoimmune etiologies.
Material And Methods: Observational, multicenter, cross-sectional study, about children with skin manifestations from April to May 2020. The diagnosis of SARS-CoV-2 was performed by PCR in nasopharyngeal exudate and/or presence of antibodies by serology.
Results: Sixty-two children were included, 9 (14.5%) presented positive antibodies to SARS-CoV-2, with no positive PCR to SARS-Cov-2 in those patients in whom it was made. Patients with positive serology to SARS-CoV-2 presented chilblains and/or vesicular-bullous skin lesions more frequently (66.7% vs. 24.5%, p=0.019). Generalized, urticarial and maculopapular rash was more common in patients with negative antibodies (37.7 vs. 0%, p=0.047), others pathogens were isolated in 41.5% of these patients. There were no significant differences in the positivity for autoantibodies between both groups.
Conclusion: In our study, the presence of chilblains-like and/or vesicular lesions were significantly related to SARS-CoV-2 previous contact.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096168 | PMC |
| http://dx.doi.org/10.1016/j.medcli.2021.03.004 | DOI Listing |
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