The main aims of the present research were 1) to characterise the inter-subject and intra-subject timing of the preparatory movements of competitive swimmers during relay starts and 2) to relate the preparatory movements with the relay start outcome. Nine international youth swimmers performed 10 relay freestyle starts (one-step technique) filmed at 120 Hz from a lateral viewpoint. Results obtained (0.14 ± 0.10 s changeover time, 0.31 ± 0.07 s entry time, 2.59 ± 0.09 m entry distance and 0.96 ± 0.06 s time to 5 m) indicated that the longer the preparation time (from the initial position to the swimmer's take-off), the better the changeover time, entry distance, and 5 m time. Specifically, a mixed linear model identified preparation time (p < 0.001, F (1,80.01) = 56.36), and entry distance (p = 0.008, F (1,80.01) = 7.36) as predicting variables for 5 m time. Also, faster swimmers on times to 5 m were found to be more consistent - lower levels of intra-subject variability - in 5 m (r = 0.76, p = 0.018) and changeover (r = 0.72, p = 0.029) times. In summary, the timing of the preparatory movements seems to be a key aspect to optimise relay start performances.
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http://dx.doi.org/10.1080/14763141.2021.1921249 | DOI Listing |
J Immunother Cancer
January 2025
Medical Oncology, Sarah Cannon Research Institute, Nashville, Tennessee, USA.
Background: SL-172154 is a hexameric fusion protein adjoining the extracellular domain of SIRPα to the extracellular domain of CD40L via an inert IgG-derived Fc domain. In preclinical studies, a murine equivalent SIRPα-Fc-CD40L fusion protein provided superior antitumor immunity in comparison to CD47- and CD40-targeted antibodies. A first-in-human phase I trial of SL-172154 was conducted in patients with platinum-resistant ovarian cancer.
View Article and Find Full Text PDFSci Adv
December 2024
West China School of Public Health and West China Fourth Hospital, West China-PUMC C.C. Chen Institute of Health, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
The hydroalkylation reaction of olefins with alkanes is a highly desirable synthetic transformation toward the construction of C(sp)─C(sp) bonds. However, such transformation has proven to be challenging for unactivated olefins, particularly when the substrates lack directing groups or acidic C(sp)─H bonds. Here, we address this challenge by merging NiH-catalyzed radical relay strategy with a HAT (hydrogen atom transfer) process.
View Article and Find Full Text PDFImportance: Neoadjuvant therapy (NT) is an increasingly used treatment strategy for patients with localized pancreatic ductal adenocarcinoma (PDAC). Little research has been conducted on cancer care delivery during NT, and the standards for optimal delivery of NT have not been defined.
Objective: To develop consensus best practices for delivering NT to patients with localized PDAC.
Front Cell Infect Microbiol
November 2024
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Objective: The fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated that is essential for virulence in a murine model of fungal keratitis (FK), suggesting the pathway could serve as a therapeutic target. Here we investigate the antifungal properties of known inhibitors of the mammalian Ire1 protein both and in a treatment model of FK.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
November 2024
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, State Key Laboratory of Petroleum Molecular and Process Engineering, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
Starting from AIEgen-functionalized chiral [2]rotaxane building block, we have successfully synthesized a new class of chiral rotaxane-branched dendrimers through controllable divergent strategy for the first time, based on which novel chiral artificial light-harvesting systems (LHSs) were successfully constructed in aqueous phase by sequentially introducing achiral donor and acceptor. More importantly, accompanied by the two-step Förster resonance energy transfer (FRET) process in the resultant artificial LHSs, the sequentially amplified circularly polarized luminescence (CPL) performances were achieved, highlighting that the chiral rotaxane-branched dendrimers could serve as excellent relay for both energy transfer and chirality transmission. Impressively, compared with the sole chiral rotaxane-branched dendrimers, the dissymmetry factors (g) values of the resultant artificial LHSs were amplified by one order of magnitude up to 0.
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