AI Article Synopsis
- - The study creates a new anticancer nanoformulation called Fc-GQD-HA that combines biocompatible nitrogen-doped graphene quantum dots with a cancer-targeting hyaluronic acid and a cancer-fighting ferrocene therapeutic.
- - The graphene quantum dots offer strong intrinsic fluorescence for tracking the formulation in lab tests, showing better internalization in cancer cells compared to non-cancer cells.
- - The Fc-GQD-HA formulation is non-toxic to normal cells but effectively kills cancer cells over time, generating three times more reactive oxygen species than the ferrocene alone, proving its targeted delivery and cancer treatment capabilities.
Article Abstract
This work develops a new multifunctional biocompatible anticancer nanoformulation to provide targeted image-guided cancer-selective therapeutics. It consists of three active covalently bound components: (1) biocompatible nitrogen-doped graphene quantum dots (GQDs) as a multifunctional delivery and imaging platform, (2) hyaluronic acid (HA) unit targeted to the CD44 receptors on a variety of cancer cells, and (3) oxidative stress-based cancer-selective ferrocene (Fc) therapeutic. The biocompatible GQD platform synthesized from glucosamine exhibits high-yield intrinsic fluorescence. It is utilized for tracking Fc-GQD-HA formulation in vitro indicating internalization enhancement in HeLa cells targeted by the HA over non-cancer HEK-293 cells not overexpressing CD44 receptor. Fc-GQD-HA, non-toxic at 1 mg/mL to HEK-293 cells, induces cytotoxic response in HeLa enhanced over time, while therapeutic ROS generation by Fc-GQD-HA is ~3 times greater than that of Fc alone. This outlines the targeted delivery, imaging, and cancer-specific treatment capabilities of the new Fc-GQD-HA formulation enabling desired cancer-focused nanotherapeutic approach.
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| http://dx.doi.org/10.1016/j.nano.2021.102408 | DOI Listing |
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