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Correction to: Cerebral cortical‑autonomic connectivity in newborns: a first step to determine the autonomic signatures with advancing age?
Clin Auton Res
December 2021
Division of Pediatric Neurology, Department of Pediatrics, UF Health Shands Children's Hospital, 1600 SW Archer Road, Gainesville, FL, 32610, USA.
Cerebral cortical-autonomic connectivity in newborns: a first step to determine the autonomic signatures with advancing age?
Clin Auton Res
June 2021
Division of Pediatric Neurology, Department of Pediatrics, UF Health Shands Children's Hospital, 1600 SW Archer Road, Gainesville, FL, 32610, USA.
From Brain to Blood Vessel: Insights From Muscle Sympathetic Nerve Recordings: Arthur C. Corcoran Memorial Lecture 2020.
Hypertension
May 2021
Sinai Health and University Health Network Division of Cardiology, Toronto General Hospital Research Institute, and the Department of Medicine, University of Toronto.
Multiunit recordings of postganglionic sympathetic outflow to muscle yield otherwise imperceptible insights into sympathetic neural modulation of human vascular resistance and blood pressure. This Corcoran Lecture will illustrate the utility of microneurography to investigate neurogenic cardiovascular regulation; review data concerning muscle sympathetic nerve activity of women and men with normal and high blood pressure; explore 2 concepts, central upregulation of muscle sympathetic outflow and cortical autonomic neuroplasticity; present sleep apnea as an imperfect model of neurogenic hypertension; and expose the paradox of sympathetic excitation without hypertension. In awake healthy normotensive individuals, resting muscle sympathetic nerve activity increases with age, sleep fragmentation, and obstructive apnea.
View Article and Find Full Text PDFCerebral cortical autonomic connectivity in low-risk term newborns.
Clin Auton Res
June 2021
Children's National Hospital, Prenatal Pediatrics Institute, 111 Michigan Ave., NW, Washington, DC, 20010, USA.
Purpose: The mature central autonomic network includes connectivity between autonomic nervous system brainstem centers and the cerebral cortex. The study objective was to evaluate the regional connectivity between the cerebral cortex and brainstem autonomic centers in term newborns by measuring coherence between high-density electroencephalography and heart rate variability as measured by electrocardiography.
Methods: Low-risk term newborns with birth gestational age of 39-40 weeks were prospectively enrolled and studied using time-synced electroencephalography and electrocardiography for up to 60 min before discharge from the birth hospital.
The aging bladder phenotype is not the direct consequence of bladder aging.
Neurourol Urodyn
November 2019
Center on Aging, UConn Health, University of Connecticut SOM, Farmington, Connecticut.
Aims: The prevalence of urinary dysfunction increases with age, yet therapies are often suboptimal. Incomplete understanding of the linkages between system, organ, and tissue domains across lifespan remains a knowledge gap. If tissue-level changes drive the aging bladder phenotype, parallel changes should be observed across these domains.
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