AI Article Synopsis
- Sugammadex is commonly used to reverse neuromuscular blockade, but studies suggest it may temporarily increase prothrombin time (PT) and activated partial thromboplastin time (aPTT).
- A review of nine studies found that while sugammadex raised PT and aPTT values compared to standard treatment, the clinical significance of these increases appears to be minor.
- The studies showed considerable variation in results, indicating a need for more rigorous research to reach definitive conclusions about sugammadex's effects on PT and aPTT.
Article Abstract
Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials' findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126340 | PMC |
| http://dx.doi.org/10.7759/cureus.14521 | DOI Listing |
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